Resultados - AvanCell-CM

Publicaciones

2022

Comparative proteomic analysis of nuclear and cytoplasmic compartments in human cardiac progenitor cells
Autores: Albericio G. et al
Journal: Sci Rep. 2022 Jan
DOI: 10.1038/s41598-021-03956-8

Generation of NKX2.5(GFP) Reporter Human iPSCs and Differentiation Into Functional Cardiac Fibroblasts
Autores: Lopez-Muneta, L. et al
Journal: Front Cell Dev Biol. 2022 Jan
DOI: 10.3389/fcell.2021.797927

Hematopoietic Stem and Progenitor Cell Mobilization and Collection for Patients Diagnosed with Osteopetrosis and Hurler Syndrome.
Sevilla J, Iriondo J, Sebastian E, et al.
Hum Gene Ther. 2022 Feb;33(3-4):213-214.
doi: 10.1089/hum.2022.29197.jse

Who should be eligible for gene therapy clinical trials in red blood cell pyruvate kinase deficiency (PKD)?: Toward an expanded definition of severe PKD.
Schwartz JD, Barcellini W, Grace RF, et al. Am J Hematol. 2022 Mar 1;97(3):E120-E125.
doi: 10.1002/ajh.26458
Epub 2022 Jan 24.

Fernández-Sevilla LM, Belenguer G, Martí-Prado B, Ortiz-Sánchez P, Ramírez M, Varas A, Fariñas I, Vicente Á. Acute lymphoblastic leukemia cells are able to infiltrate the brain subventricular zone stem cell niche and impair neurogenesis. Haematologica. 2022 Apr 1;107(4):1004-1007. doi: 10.3324/haematol.2021.279383 PMID: 35045691

Fernández-Sevilla LM, Valencia J, Ortiz-Sánchez P, Fraile-Ramos A, Zuluaga P, Jiménez E, Sacedón R, Martínez-Sánchez MV, Jazbec J, Debeljak M, Fedders B, Stanulla M, Schewe DM, Cario G, Minguela A, Ramírez M, Varas A, Vicente Á. High BMP4 expression in low/intermediate risk BCP-ALL identifies children with poor outcome. Blood. 2022 Mar 22:blood.2021013506. doi: 10.1182/blood.2021013506 Online ahead of print. PMID: 35313334

Marins-Dos-Santos A, Ayres-Silva JP, Antunes D, Carvalho Moreira CJ, Pelajo-Machado M, Alfaro D, Zapata AG, Bonomo AC, Savino W, de Meis J, Farias-de-Oliveira DA. Oral Trypanosoma cruzi Acute Infection in Mice Targets Primary Lymphoid Organs and Triggers Extramedullary Hematopoiesis. Front. Cell. Infect. Microbiol., 24 March 2022 | https://doi.org/10.3389/fcimb.2022.800395

2021

Hallmarks of the human intestinal microbiome on liver maturation and function. Almeida J, Tenreiro M, Martinez-Santamaria L, Guerrero Aspizua S, Gisbert JP, Alves PM, Serra M, Baptista PM. 2021. Journal of Hepatology 76 (3):694-725.
PMID: 34715263. doi: 10.1016/j.jhep.2021.10.015
https://www.sciencedirect.com/science/article/pii/S0168827821021528?via%3Dihub

DNA Repair and Immune Response Pathways Are Deregulated in Melanocyte-Keratinocyte Co-cultures Derived From the Healthy Skin of Familial Melanoma Patients. Potrony M, Haddad TS, Tell-Martí G, Gimenez-Xavier P, Leon C, Pevida M, Mateu J, Badenas C, Carrera C, Malvehy J, Aguilera P, Llames S, Escámez MJ, Puig-Butillé JA, Del Río M, Puig S. 2021. Frontiers in Medicine. 8: 692341
PMID: 34660619 doi: 10.3389/fmed.2021.692341
https://www.frontiersin.org/articles/10.3389/fmed.2021.692341/full

Immunotherapeutic effect of adenovirus encoding antimicrobial peptides in experimental pulmonary tuberculosis. Ramos-Espinosa O, Mata-Espinosa D, Francisco-Cruz A, López-Torres MO, Hernández-Bazán S, Barrios-Payán J, Marquina-Castillo B, Carretero M, Del Río M, Hernández-Pando R. 2021. Journal of Leukocyte Biology. 110(5):951-963
PMID: 33682193 doi: 10.1002/JLB.4MA0920-627R
https://jlb.onlinelibrary.wiley.com/doi/10.1002/JLB.4MA0920-627R

Transcriptomic Analysis of a Diabetic Skin-Humanized Mouse Model Dissects Molecular Pathways Underlying the Delayed Wound Healing Response. León C, García-García F, Llames S, García-Pérez E, Carretero M, Arriba MC, Dopazo J, Del Río M, Escámez MJ, Martínez-Santamaría L. 2021. Genes. 12(1): 47
PMID: 33396192 doi: 10.3390/genes12010047
https://www.mdpi.com/2073-4425/12/1/47

Natural occurrence of autoantibodies against basement membrane proteins in epidermolysis bullosa. Gostyński A, Gilles F.H. Diercks, Maria-José Escamez, Nisha Suyien Chandran, Raúl de Lucas, Adela Garcia-Martin, Marcela Del Rio, Jeroen Bremer, Maria C. Bolling, Alvaro Meana, Sara G. Llames, Enno Schmidt, Ralf Ludwig, Marcel F. Jonkman, Hendri H. Pas and Anna M.G. Pasmooij. 2021. Journal of Investigative Dermatology. S0022-202X(21)02584-7.
PMID: 34843678 doi: 10.1016/j.jid.2021.10.030
https://www.sciencedirect.com/science/article/pii/S0022202X21025847?via%3Dihub

Formyl Peptide Receptor 2 DNA aptamers for targeted therapy of wound repair. Arriba MC*, Fernández G*, Chacón-Solano E, Martínez-Santamaría L, Illera N, Carrión R, Martín M, Larcher F, González V, Del Río M, Carretero M. 2022. Journal of Investigative Dermatology. S0022-202X(21)02688-9.
PMID: 34979109 doi: 10.1016/j.jid.2021.12.026
https://www.sciencedirect.com/science/article/abs/pii/S0022202X21026889?via%3Dihub

Epidermolysis Bullosa in Spain: Observational Study of a Cohort of Patients Treated in a National Referral Center. Maseda Pedrero R, Quintana Castanedo L, Pérez Conde I, Jiménez González M, Escámez Toledano MJ, de Lucas Laguna R. 2021. Actas Dermo-Sifiliográficas. 112:781-793
PMID: 33984313. doi: 10.1016/j.ad.2021.04.006
https://www.sciencedirect.com/science/article/pii/S0001731021001769?via%3Dihub

Next-generation Sequencing in Bone Marrow Failure Syndromes and Isolated Cytopenias: Experience of the Spanish Network on Bone Marrow Failure Syndromes. Gálvez E, Vallespín E, Arias-Salgado EG, et al. Hemasphere. 2021 Mar 9;5(4):e539. doi: 10.1097/HS9.0000000000000539 eCollection 2021 Apr.

Haplo-identical or mismatched unrelated donor hematopoietic cell transplantation for Fanconi anemia: Results from the Severe Aplastic Anemia Working Party of the EBMT. Zubicaray J, Pagliara D, Sevilla J, et al. Am J Hematol. 2021 May 1;96(5):571-579. doi: 10.1002/ajh.26135 Epub 2021 Mar 4.

Plerixafor-based mobilization in pediatric healthy donors with unfavorable donor/recipient body weight ratio resulted in a better CD34+ collection yield: A retrospective analysis. Zubicaray J, Galvez E, Sebastian E, et al. J Clin Apher. 2021 Feb;36(1):78-86. doi: 10.1002/jca.21844 Epub 2020 Oct 20.

Improved collection of hematopoietic stem cells and progenitors from Fanconi anemia patients for gene therapy purposes. Sevilla J, Navarro S, Rio P, et al. Mol Ther Methods Clin Dev. 2021 Jun 12;22:66-75. doi: 10.1016/j.omtm.2021.06.001 Collection 2021 Sep 10.

CRISPR-Cas9 Technology as a Tool to Target Gene Drivers in Cancer: Proof of Concept and New Opportunities to Treat Chronic Myeloid Leukemia. Vuelta E, Ordoñez JL, Alonso-Pérez V, et al. CRISPR J. 2021 Aug;4(4):519-535. doi: 10.1089/crispr.2021.0009

Graft failure after "ex-vivo" T-cell depleted haploidentical transplantation in pediatric patients with high-risk hematological malignancies. A risk factors and outcomes analysis. Diaz MA, Lopez I, Molina B, Pereto A, et al. Leuk Lymphoma. 2021 Dec;62(13):3130-3137. doi: 10.1080/10428194.2021.1953018 Epub 2021 Jul 15.

Natural gene therapy by reverse mosaicism leads to improved hematology in Fanconi anemia patients. Ramírez MJ, Pujol R, Trujillo-Quintero JP, et al. Am J Hematol. 2021 Aug 1;96(8):989-999. doi: 10.1002/ajh.26234 Epub 2021 May 25.

Systemic Treatment of Immune-Mediated Keratoconjunctivitis Sicca with Allogeneic Stem Cells Improves the Schirmer Tear Test Score in a Canine Spontaneous Model of Disease. Manuel Hermida-Prieto, Javier García-Castro, Luis Mariñas-Pardo. J Clin Med. 2021 Dec; 10(24): 5981 doi: 10.3390/jcm10245981

RGB-Marking to Identify Patterns of Selection and Neutral Evolution in Human Osteosarcoma Models. Stefano Gambera, Ana Patiño-Garcia, Arantzazu Alfranca, Javier Garcia-Castro. Cancers (Basel) 2021 May; 13(9): 2003. Published online 2021 Apr 21. doi: 10.3390/cancers13092003

Combination immunotherapy using G-CSF and oncolytic virotherapy reduces tumor growth in osteosarcoma. Alvaro Morales-Molina, Stefano Gambera, Angela Leo, Javier García-Castro. J Immunother Cancer. 2021; 9(3): e001703 DOI: 10.1136/jitc-2020-001703

Improving the Efficacy of Mesenchymal Stem/Stromal-Based Therapy for Treatment of Inflammatory Bowel Diseases.
Autores: Lopez-Santalla M. et al
Biomedicines. 2021 Oct
DOI: 10.3390/biomedicines9111507

Mechanism of Immunoregulatory Properties of Vasoactive Intestinal Peptide in the K/BxN Mice Model of Autoimmune Arthritis
Autores: Leceta, J, et al
Frontiers in Immunology. 2021 Jul
DOI: 10.3389/fimmu.2021.701862

Mesenchymal stem/stromal cell-based therapy for the treatment of rheumatoid arthritis: An update on preclinical studies
Autores: Lopez-Santalla, M, et al.
EBioMedicine. 2021 Jun.
DOI: 10.1016/j.ebiom.2021.103427

Enhanced Susceptibility of Galectin-1 Deficient Mice to Experimental Colitis
Autores: Fernandez-Perez, Raquel, et al.
Frontiers in Immunology. 2021 Jun.
DOI: 10.3389/fimmu.2021.687443

Generating New FANCA-Deficient HNSCC Cell Lines by Genomic Editing Recapitulates the Cellular Phenotypes of Fanconi Anemia
Autores: Errazquin, Ricardo, et al.
Genes. 2021 Mar.
DOI: 10.3390/genes12040548

GSE4-loaded nanoparticles a potential therapy for lung fibrosis that enhances pneumocyte growth, reduces apoptosis and DNA damage
Autores: Laura Pintado Berniches, et al.
Faseb Journal. 2021 Mar;35(3):e21422..
DOI: 10.1096/fj.202001160RR

Next-generation Sequencing in Bone Marrow Failure Syndromes and Isolated Cytopenias: Experience of the Spanish Network on Bone Marrow Failure Syndromes
Autores: Eva Gálvez, et al.
Hemasphere. 2021 Mar 9;5(4):e539.
DOI: 10.1097/HS9.0000000000000539

The Current Status of Mesenchymal Stromal Cells: Controversies, Unresolved Issues and Some Promising Solutions to Improve Their Therapeutic Efficacy
Autores: García-Bernal D, et al.
Front. Cell Dev. Biol. 9:650664 (2021).
DOI: 10.3389/fcell.2021.650664

Enhanced anti-inflammatory effects of mesenchymal stromal cells mediated by the transient ectopic expression of CXCR4 and IL10
Autores: Hervás-Salcedo R, et al.
Stem Cell Res Ther 2021 Feb 12;12(1):124.
DOI: 10.1186/s13287-021-02193-0

Generation of dyskeratosis congenita-like hematopoietic stem cells through the stable inhibition of DKC1
Autores: Carrascoso-Rubio C, et al.
Stem Cell Res Ther 2021 Jan 29;12(1):92.
DOI: 10.1186/s13287-021-02145-8

Xeno-free approach for the expansion of human adipose derived mesenchymal stem cells for ocular therapies. Persinal-Medina M, Llames S, Vázquez N, Chacón M, Acebes-Huerta A, Uribe E, Alonso-Alonso S, Fernández-Vega González C, Baamonde B, Quirós L, Merayo-Lloves J, Meana Á.
2021. Exp Eye Res. 202: 108358.
PMID: 33207223 doi: 10.1016/j.exer.2020.108358
https://www.sciencedirect.com/science/article/abs/pii/S0014483520306163

García-Bernal D, García-Arranz M, Yáñez RM, Hervás-Salcedo R, Cortés A, Fernández-García M, Hernando-Rodríguez M, Quintana-Bustamante Ó, Bueren JA, García-Olmo D, Moraleda JM, Segovia JC, Zapata AG. The Current Status of Mesenchymal Stromal Cells: Controversies, Unresolved Issues and Some Promising Solutions to Improve Their Therapeutic Efficacy. Front Cell Dev Biol. 2021 Mar 16;9:650664. doi: 10.3389/fcell.2021.650664 eCollection 2021. PMID: 33796536. I.F. (2019): 5.186 Q1.

Montero-Herradón S, García-Ceca J, Zapata AG. How Many Thymic Epithelial Cells Are Necessary for a Proper Maturation of Thymocytes? Front Immunol. 2021 Mar 8;12:618216. doi: 10.3389/fimmu.2021.618216 eCollection 2021. PMID: 33763065. Review.

Gómez-Ferrer M, Amaro-Prellezo E, Dorronsoro A, Sánchez-Sánchez R, Vicente A, Cosín-Roger J, Barrachina MD, Baquero MC, Valencia J, Sepúlveda P. HIF-overexpression and pro-inflammatory priming in human mesenchymal stromal cells improves the healing properties of extracellular vesicles in experimental Crohn’s disease. International Journal of Molecular Sciences. 2021, 22:11269. doi.org/10.3390/ijms222011269

Fañanas-Baquero S, Orman I, Becerra Aparicio F, Bermudez de Miguel S, Garcia Merino J, Yañez R, Fernandez Sainz Y, Sánchez R, Dessy-Rodríguez M, Alberquilla O, Alfaro D, Zapata A, Bueren JA, Segovia JC, Quintana-Bustamante O. Natural estrogens enhance the engraftment of human hematopoietic stem and progenitor cells in immunodeficient mice. Haematologica. 2021 Jun 1;106(6):1659-1670. doi: 10.3324/haematol.2019.233924 PMID: 32354868.

Montero-Herradón S, Zapata AG. Delayed maturation of thymic epithelium in mice with specific deletion of β-catenin gene in FoxN1 positive cells. Histochem Cell Biol. 2021 Jul 12. doi: 10.1007/s00418-021-02012-w Online ahead of print. PMID: 34254201

2020

Development of an in-house reconstructed human epidermis model as an alternative method in skin corrosion assessment. Chacón M, Vázquez N, Persinal-Medina M, Alonso-Alonso S, Pevida M, Llames S, Baamonde B, Quiros L, Merayo-Lloves J, Meana Á.
2020. Toxicol In Vitro.65:104779.
PMID: 31962200 doi: 10.1016/j.tiv.2020.104779
https://www.sciencedirect.com/science/article/abs/pii/S0887233319309014?via%3Dihub

Advanced Statistical Techniques for Noninvasive Hyperglycemic States Detection in Mice Using Millimeter-Wave Spectroscopy. Moreno-Oyervides A, Aguilera-Morillo MC, Larcher F, Krozer V, Acedo P.
2020. IEEE Transactions on Terahertz Science and Technology. 10(3): 237-245
doi: 10.1109/TTHZ.2020.2967236
https://ieeexplore.ieee.org/document/8961090

Combined adipose mesenchymal stromal cell advanced therapy resolve a recalcitrant leg ulcer in an 85 –year.old patient. Martínez-Santamaría L, Cárcamo C, García-Pardo L, García-Arranz M, Melen G, Guerrero-Aspizua S, Llanos L, Del Río M, García-Olmo D, Escámez MJ.
2020. Regenerative Medicine. 15(9):2053-2065
PMID: 33245008 doi: 10.2217/rme-2020-0139
https://www.futuremedicine.com/doi/pdf/10.2217/rme-2020-0139

Nonlinear Image Registration and Pixel Classification Pipeline for the Study of Tumor Heterogeneity Maps. Nicolás-Sáenz L, Guerrero-Aspizua S, Pascau J, Muñoz-Barrutia A.
2020. Entropy (Basel). 22(9):946.
PMID: 33286715 doi: 10.3390/e22090946
https://www.mdpi.com/1099-4300/22/9/946

Foodomics evaluation of the anti-proliferative potential of Passiflora mollissima seeds. Ballesteros-Vivas D, Alvarez-Rivera G, León C, Morantes SJ, Ibánez E, Parada-Alfonso F, Cifuentes A, Valdés A.
2020. Food Res Int.130:108938.
PMID: 32156385. doi: 10.1016/j.foodres.2019.108938
https://www.sciencedirect.com/science/article/abs/pii/S0963996919308245?via%3Dihub

Raloxifene and n-Acetylcysteine Ameliorate TGF-Signalling in Fibroblasts from Patients with Recessive Dominant Epidermolysis Bullosa.
Aguado T, García M, García A, Ferrer-Mayorga G, Martínez-Santamaría L, Del Río M, Botella LM, Sánchez-Puelles JM.
2020 Cells. 9(9):2108
PMID: 32947957 doi: 10.3390/cells9092108
https://www.mdpi.com/2073-4409/9/9/2108

The importance of immunity in the development of reliable animal models for psoriasis and atopic dermatitis. Guerrero-Aspizua S, Carretero M, Conti CJ, Del Río M.
2020. Immunol Cell Biol. 98(8):626-638.
PMID: 32479655 doi: 10.1111/imcb.12365
https://onlinelibrary.wiley.com/doi/10.1111/imcb.12365

Beneficial effect of systemic allogeneic adipose derived mesenchymal cells on the clinical, inflammatory and immunologic status of a patient with recessive dystrophic epidermolysis bullosa: a case report. Maseda R, Martinez-Santamaria L, Sacedón R, Butta N, Arriba MC, García-Barcenilla S, Marta García M, Illera N, Pérez-Conde I, Carretero M, Jiménez E, Melen G, Borobia AM, Jiménez-Yuste V, Vicente Á, del Río M, de Lucas R, Escámez MJ
2020. Front. Med. 7:576558.
PMID: 33324660 doi: 10.3389/fmed.2020.576558
https://www.frontiersin.org/articles/10.3389/fmed.2020.576558/abstract

Clinical practice guidelines for laboratory diagnosis of epidermolysis bullosa. Bolling M, Charlesworth AV, El Hachem M, Escámez MJ, Fuentes I, Büchel S, Hiremagalore R, Pohla-Gubo G, van den Akker P, Wertheim-Tysarowska K, Zambruno G.
2020. Br J Dermatol. 182(3):574-592
PMID: 31090061 doi: 10.1111/bjd.18128
https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.18128

Humanization of Tumor Stroma by Tissue Engineering as a Tool to Improve Squamous Cell Carcinoma Xenograft. Guerrero-Aspizua S, González-Masa A, Conti CJ, García M, Chacón-Solano E,Larcher F, Del Río M.
2020. Int J Mol Sci. 21(6):1951.
PMID: 32178458 doi: 10.3390/ijms21061951
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139348/

Efficient CRISPR-Cas9-Mediated Gene Ablation in Human Keratinocytes to Recapitulate Genodermatoses: Modeling of Netherton Syndrome. Gálvez V, Chacón-Solano E, Bonafont J, Mencía Á, Di WL, Murillas R, Llames S, Vicente A, Del Rio M, Carretero M,Larcher F.
2020. Mol Ther Methods Clin Dev. 18:280-290.
PMID: 32637457 doi: 10.1016/j.omtm.2020.05.031
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329935/

Emapalumab in Children with Primary Hemophagocytic Lymphohistiocytosis. Locatelli F, Jordan MB, Allen C, et al. N Engl J Med. 2020 May 7;382(19):1811-1822. doi: 10.1056/NEJMoa1911326

Plerixafor combined with standard regimens for hematopoietic stem cell mobilization in pediatric patients with solid tumors eligible for autologous transplants: two-arm phase I/II study (MOZAIC). Morland B, Kepak T, Dallorso S, et al. Bone Marrow Transplant. 2020 Sep;55(9):1744-1753. doi: 10.1038/s41409-020-0836-2 Epub 2020 Mar 3.

First-in-Human, First-in-Child Trial of Autologous MSCs Carrying the Oncolytic Virus Icovir-5 in Patients with Advanced Tumors. David Ruano, José A. López-Martín, Lucas Moreno, Álvaro Lassaletta, Francisco Bautista, Maitane Andión, Carmen Hernández, África González-Murillo, Gustavo Melen, Ramón Alemany, Luis Madero, Javier García-Castro, Manuel Ramírez. Mol Ther. 2020 Apr 8; 28(4): 1033–1042. DOI: 10.1016/j.ymthe.2020.01.019

Targeted gene therapy into a safe harbor site in human hematopoietic progenitor cells
Autores: Rodriguez-Fornes, F.. et al.
Gene Ther. 2020 Sep;27(9):435-450
DOI: 10.1038/s41434-020-0144-x

Theranostic Viral Nanoparticles for Autoimmune Diseases.
Autores: Yuste-Calvo, C.. et al.
J Immuno Biol Volume 5:1, 2020
DOI: 10.37421/JIB.2020.5.149

Mesenchymal Stem/Stromal Cells for Rheumatoid Arthritis Treatment: An Update on Clinical Applications
Autores: Lopez-Santalla, M. et al.
Cells. 2020 Aug 7;9(8).
DOI: 10.3390/cells9081852

Human Pluripotent Stem Cell-Derived Neurons Are Functionally Mature In Vitro and Integrate into the Mouse Striatum Following Transplantation.
Autores: Comella-Bolla, A.. et al.
Mol Neurobiol. 2020 Jun;57(6):2766-2798
DOI: 10.1007/s12035-020-01907-4

Gefitinib and afatinib show potential efficacy for Fanconi anemia-related head and neck cancer
Autores: Montanuy, Helena. et al.
Clin Cancer Res 2020 Jun 15;26(12):3044-3057
DOI: 10.1158/1078-0432.ccr-19-1625

Cell Therapy With Mesenchymal Stem Cells Induces an Innate Immune Memory Response That Attenuates Experimental Colitis in the Long Term
Autores: Lopez-Santalla, M. et al.
Journal of Crohn's and Colitis, 2020, 1–12.
DOI: 10.1093/ecco-jcc/jjaa079

Natural estrogens enhance the engraftment of human hematopoietic stem and progenitor cells in immunodeficient mice.
Autores: Fañanas-Baquero, S. et al.
Haematologica. 2020 Apr 30.
DOI: 10.3324/haematol.2019.233924

The downregulated membrane expression of CD18 in CD34(+) cells defines a primitive population of human hematopoietic stem cells
Autores: Mesa-Nuñez, C. et al.
Stem Cell Res Ther. 2020 Apr 28;11(1):164.
DOI: 10.1186/s13287-020-01672-0

TALEN mediated gene editing in a mouse model of Fanconi anemia.
Autores: Pino-Barrio, M. J. et al.
Sci Rep. 2020 Apr 24;10(1):6997
DOI: 10.1038/s41598-020-63971-z

Optimised molecular genetic diagnostics of Fanconi anaemia by whole exome sequencing and functional studies.
Autores: Bogliolo, M. et al.
Bogliolo M, et al. J Med Genet 2019;0:1–11.
DOI: 10.1136/jmedgenet-2019-106249

Helios modulates the maturation of a CA1 neuronal subpopulation required for spatial memory formation.
Autores: Giralt, A. et al.
Exp Neurol. 2020 Jan;323:113095.
DOI: 10.1016/j.expneurol.2019.113095

IKKbeta overexpression together with a lack of tumour suppressor genes causes ameloblastic odontomas in mice.
Autores: Page, A.. et al.
Int J Oral Sci. 2020 Jan 2;12(1):1. .
DOI: 10.1038/s41368-019-0067-9

Advances in the Gene Therapy of Monogenic Blood Cell Diseases.
Autores: J. A. Bueren, O. Quintana-Bustamante, E. Almarza, S. Navarro, P. Río, J. C. Segovia and G. Guenechea
Clinical Genetics,31231794
doi: 10.1111/cge.13593

Clinical Practice Guidelines for Epidermolysis Bullosa Laboratory Diagnosis. Has C, Liu L, Bolling M, Charlesworth AV, El Hachem M, Escámez MJ, Fuentes I, Büchel S, Hiremagalore R, Pohla-Gubo G, van den Akker P, Wertheim-Tysarowska K, Zambruno G. 2020. Br J Dermatol. 182(3): 574-592.
PMID: 31090061 doi: 10.1111/bjd.18128
https://onlinelibrary.wiley.com/doi/10.1111/bjd.18128

Libro: Quílez C, de Aranda Izuzquiza G, García M, López V, Montero A, Valencia L, Velasco D. Bioprinting for Skin. 2020. In: Crook J (eds) 3D Bioprinting. Methods in Molecular Biology. Humana, New York, NY. Vol 2140: 263 pp. ISBN 978-1-0716-0519-6.
PMID: 32207115 doi: 10.1007/978-1-0716-0520-2_14
https://link.springer.com/protocol/10.1007%2F978-1-0716-0520-2_14

Capítulo de libro: León C, Cifuentes A. 15-Foodomics evaluation of genetically modified organisms. 2020. In Pico Y (eds) Chemical Analysis of Food 2ndEd. Academic Press: 657-695. ISBN 9780128132661.
https://doi.org/10.1016/B978-0-12-813266-1.00015-2
https://www.sciencedirect.com/science/article/pii/B9780128132661000152?via%3Dihub

Sánchez-Guijo F, García-Olmo D, Prósper F, Martínez S, Zapata A, Fernández-Avilés F, Toledo-Aral JJ, Torres M, Fariñas I, Badimón L, Labandeira-García JL, García-Sancho J, Moraleda JM. Spanish Cell Therapy Network (TerCel): 15 years of successful collaborative translational research. Cytotherapy. 2020 Jan;22(1):1-5. doi: 10.1016/j.jcyt.2019.11.001 Epub 2019 Dec 19.PMID: 31866320.

Alfaro D, Rodríguez-Sosa MR, Zapata AG. Eph/ephrin Signaling and Biology of Mesenchymal Stromal/Stem Cells. J Clin Med. 2020 Jan 22;9(2):310. doi: 10.3390/jcm9020310. PMID: 31979096

García-Ceca J, Montero-Herradón S, Zapata AG. Thymus aging in mice deficient in either EphB2 or EphB3, two master regulators of thymic epithelium development. Dev Dyn. 2020 Oct; 249(10):1243-1258. doi: 10.1002/dvdy.212 Epub 2020 Jun 25. PMID: 32506584

Sánchez-Guijo F, García-Arranz M, López-Parra M, Monedero P, Mata-Martínez C, Santos A, Sagredo V, Álvarez-Avello JM, Guerrero JE, Pérez-Calvo C, Sánchez-Hernández MV, Del-Pozo JL, Andreu EJ, Fernández-Santos ME, Soria-Juan B, Hernández-Blasco LM, Andreu E, Sempere JM, Zapata AG, Moraleda JM, Soria B, Fernández-Avilés F, García-Olmo D, Prósper F. Adipose-derived mesenchymal stromal cells for the treatment of patients with severe SARS-CoV-2 pneumonia requiring mechanical ventilation. A proof-of-concept study. EClinicalMedicine. 2020 Aug;25:100454. doi: 10.1016/j.eclinm.2020.100454 Epub 2020 Jul 10.

García-Ceca J, Montero-Herradón S, Zapata AG. Intrathymic Selection and Defects in the Thymic Epithelial Cell Development. Cells. 2020 Oct 2;9(10):2226. doi: 10.3390/cells9102226. PMID: 33023072

Fernández-Sevilla LM, Valencia J, Flores-Villalobos MA, González-Murillo A, Sacedón R, Jiménez E, Ramírez M, Varas A, Vicente A. The choroid plexus stroma constitutes a sanctuary for paediatric B-cell precursor acute lymphoblastic leukaemia in the Central Nervous System. Journal of Pathology. 2020 Oct;252(2):189-200. doi: 10.1002/path.5510 PMID: 32686161.

Vázquez A, Fernández-Sevilla LM, Jiménez E, Pérez-Cabrera D, Yañez R, Subiza JL, Varas A, Valencia J, Vicente A. Involvement of mesenchymal stem cells in oral mucosal bacterial immunotherapy. Frontiers in Immunology. 2020 Nov 19; 11:567391. doi: 10.3389/fimmu.2020.567391 PMID: 33329530.

Maseda R, Martínez-Santamaría L, Sacedón R, Butta N, de Arriba MDC, García-Barcenilla S, García M, Illera N, Pérez-Conde I, Carretero M, Jiménez E, Melen G, Borobia AM, Jiménez-Yuste V, Vicente Á, Del Río M, de Lucas R, Escámez MJ. Beneficial effect of systemic allogeneic adipose derived mesenchymal cells on the clinical, inflammatory and immunologic status of a patient with recessive dystrophic epidermolysis bullosa: A case report. Frontiers in Medicine (Lausanne). 2020 Nov 26; 7:576558. doi: 10.3389/fmed.2020.576558 PMID: 33324660.

García-Bernal D, García-Arranz M, García-Guillén AI, García-Hernández AM, Blanquer M, García-Olmo D, Sackstein R, Moraleda JM, Zapata AG. Exofucosylation of Adipose Mesenchymal Stromal Cells Alters Their Secretome Profile. Front Cell Dev Biol. 2020 Nov 26;8:584074. doi: 10.3389/fcell.2020.584074 eCollection 2020. PMID: 33324641.

Zapata, A.G. Inmunología comparada. Inmunología (Biología y patología del sistema inmunitario). Editorial Panamericana. Sept. 2020.

2019

Clinically Relevant Correction of Recessive Dystrophic Epidermolysis Bullosa by Dual sgRNA CRISPR/Cas9-Mediated Gene Editing. Bonafont J, Mencía Á, García M, Torres R, Rodríguez S, Carretero M, Chacón-Solano E, Modamio-Høybjør S, Marinas L, León C, Escamez MJ, Hausser I, Del Río M, Murillas R, Larcher F.
2019. Mol Ther. 27(5):986-998.
PMID: 30930113 doi: 10.1016/j.ymthe.2019.03.007
https://www.sciencedirect.com/science/article/pii/S1525001619300930?via%3Dihub

Fibroblast activation and abnormal extracellular matrix remodelling as common hallmarks in three cancer-prone genodermatoses. Chacón-Solano E, León C, Díaz F, García-García F, García M, Escámez MJ, Guerrero-Aspizua S, Conti CJ, Mencía Á, Martínez-Santamaría L, Llames S, Pévida M, Carbonell-Caballero J, Puig-Butillé JA, Maseda R, Puig S, de Lucas R, Baselga E, Larcher F, Dopazo J, Del Río M. 2019. Br J Dermatol. 181(3):512-522.
PMID: 30693469 doi: 10.1111/bjd.17698
https://onlinelibrary.wiley.com/doi/full/10.1111/bjd.17698

Safety and efficacy outcomes for lentiviral autologous fibroblast gene therapy in adults with recessive dystrophic epidermolysis bullosa. Lwin SM, Syed F, Di W-L, Kadiyirire T, Liu L, Guy A, Petrova A, Abdul-Wahab A, Reid F, Phillips R, Elstad M, Georgiadis C, Aristodemou S, Lovell PA, McMillan JR, Mee J, Miskinyte S, Titeux M, Ozoemena L, Pramanik R, Serrano S, Rowles R, Maurin C, Orrin E, Martinez-Queipo M, Rashidghamat E, Tziotzios C, Onoufriadis A, Chen M, Chan L, Farzaneh F, Del Río M, Tolar J, Bauer J W, Larcher F, Antoniou MN, Hovnanian A, Thrasher AJ, Mellerio JE, Qasim W, McGrath JA.
2019. Journal of clinical investigation Insight. 4(11): e126243.
PMID: 31167965 doi: 10.1172/jci.insight.126243SM
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629162/pdf/jciinsight-4-126243.pdf

Assessment of the risk and characterization of non-melanoma skin cancer in Kindler syndrome: study of a series of 91 patients. Guerrero-Aspizua S, Conti CJ, Escamez MJ, Castiglia D, Zambruno G, Youssefian L, Vahidnezhad H, Requena L, Itin P, Tadini G, Yordanova I, Martín L, Uitto J, Has C and Del Río M.
2019. Orphanet J Rare Dis. 2019 Jul 24;14(1):183.
PMID: 31340837 doi: 10.1186/s13023-019-1158-6
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657209/pdf/13023_2019_Article_1158.pdf

Human plasma gels: Their preparation and rheological characterization for cell culture applications in tissue engineering. Barreda L, Marcet I, Llames S, Pevida M, García-Pérez E, Meana Á, Rendueles M, Díaz M.
2019. J Mech Behav Biomed Mater. 89:107-113.
PMID: 30267992 doi: 10.1016/j.jmbbm.2018.09.015
https://www.sciencedirect.com/science/article/pii/S1751616118301553?via%3Dihub

Early, Non-Invasive Sensing of Sustained Hyperglycemia in Mice Using Millimeter-Wave Spectroscopy. Moreno-Oyervides A, Martín-Mateos P, Aguilera-Morillo MC, Ulisse G, Arriba MC, Durban M, Del Río M, Larcher F, Krozer V, Acedo P.
2019. Sensors (Basel). 19(15):3347.
PMID: 31366169 doi: 10.3390/s19153347
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695793/pdf/sensors-19-03347.pdf

Epidemiology and natural history of cutaneous squamous cell carcinoma in recessive dystrophic epidermolysis bullosa patients: 20 years' experience of a reference centre in Spain. Castelo B, Viñal D, Maseda R, Ostios L, Sánchez D, García-Salvatierra B, Escámez MJ, Martínez-Santamaría L, Del Río M, Mora-Rillo M, Vilches Y, Beato MJ, López Gutiérrez JC, Romero N, Santos C, Miranda J, de Lucas R.
2019. Clin Transl Oncol. 21(11):1573-1577
PMID: 30864020 doi: 10.1007/s12094-019-02073-3
https://link.springer.com/article/10.1007%2Fs12094-019-02073-3

Anti-proliferative bioactivity against HT-29 colon cancer cells of a withanolides-rich extract from golden berry (Physalis peruviana L.) calyx investigated by Foodomics. Ballesteros-Vivas D, Alvarez-Rivera G, León C, Morantes SJ, Ibánez E, Parada-Alfonso F, Cifuentes A, Valdés A. 2019. Journal of Functional Foods. 63: 103567,
PMID: 33286715 doi: 10.3390/e22090946
https://www.sciencedirect.com/science/article/abs/pii/S1756464619304918

Haploidentical Stem Cell Transplantation in Children With Hematological Malignancies Using αβ+ T-Cell Receptor and CD19+ Cell Depleted Grafts: High CD56dim/CD56bright NK Cell Ratio Early Following Transplantation Is Associated With Lower Relapse Incidence and Better Outcome. Diaz MA, Zubicaray J, Molina B, et al. Front Immunol. 2019 Oct 30;10:2504. doi: 10.3389/fimmu.2019.02504 eCollection 2019.

Successful engraftment of gene-corrected hematopoietic stem cells in non-conditioned patients with Fanconi anemia. Río P, Navarro S, Wang W, et al. Nat Med. 2019 Sep;25(9):1396-1401. doi: 10.1038/s41591-019-0550-z Epub 2019 Sep 9.

Genetic analyses of aplastic anemia and idiopathic pulmonary fibrosis patients with short telomeres, possible implication of DNA-repair genes. Arias-Salgado EG, Galvez E, Planas-Cerezales L, et al. Orphanet J Rare Dis. 2019 Apr 17;14(1):82. doi: 10.1186/s13023-019-1046-0

Gene editing of PKLR gene in human hematopoietic progenitors through 5' and 3' UTR modified TALEN mRNA
Autores: Quintana-Bustamante, O. et al.
PLoS One. 2019 Oct 16;14(10):e0223775.
DOI: 10.1371/journal.pone.0223775

Inhibition of a G9a/DNMT network triggers immune-mediated bladder cancer regression
Autores: Segovia, C, et al.
Nature Medicine. 2019 Jul;25(7):1073-1081
doi: 10.1038/s41591-019-0499

Elongated Flexuous Plant Virus-Derived Nanoparticles Functionalized for Autoantibody Detection
Autores: Yuste-Calvo, C. Lopez-Santalla, M. Zurita, L.
Cruz-Fernandez, C. F. Sanchez, F. Garin, M. I.Ponz, F.
Nanomaterials (Basel). 2019 Oct 10;9(10)
https://doi.org/10.3390/nano9101438

NHEJ-Mediated Repair of CRISPR-Cas9-Induced DNA Breaks Efficiently Corrects Mutations in HSPCs from Patients with Fanconi Anemia
Autores: Francisco Jose Román-Rodrıguez, Laura Ugalde, Lara A´ lvarez,Begoña Díez,María José Ramırez, Cristina Risueño, Marta Cortón, Massimo Bogliolo, Sara Bernal, Francesca March, Carmen Ayuso, Helmut Hanenberg, Julián Sevilla, Sandra Rodríguez-Perales, Raúl Torres-Ruíz, Jordi Surralles, Juan Antonio Bueren and Paula Río
Cell Stem Cell 25, 1–15.
https://doi.org/10.1016/j.stem.2019.08.016

Successful engraftment of gene-corrected hematopoietic stem cells in non-conditioned patients with Fanconi anemia
Autores: Río, P., S. Navarro, W. Wang, R. Sánchez-Domínguez, R. M. Pujol, J. C. Segovia, M. Bogliolo, E. Merino, N. Wu, R. Salgado, M. L. Lamana, R. M. Yañez, J. A. Casado, Y. Giménez, F. J. Román-Rodríguez, L. Álvarez, O. Alberquilla, A. Raimbault, G. Guenechea, M. L. Lozano, L. Cerrato, M. Hernando, E. Gálvez, R. Hladun, I. Giralt, J. Barquinero, A. Galy, N. García de Andoín, R. López, A. Catalá, J. D. Schwartz, J. Surrallés, J. Soulier, M. Schmidt, C. Díaz de Heredia, J. Sevilla and J. A. Bueren (2019)
Nature Medicine 25(9): 1396-1401. DOI: 10.1038/s41591-019-0550-z

GSE4 peptide suppresses oxidative and telomere deficiencies in ataxia telangiectasia patient cells
Autores: L. Pintado-Berninches, B. Fernandez-Varas, C. Benitez-Buelga, C. Manguan-Garcia, A. Serrano-Benitez, L. Iarriccio, J. Carrillo, G. Guenechea, S. P. Egusquiaguirre, J. L. Pedraz, R. M. Hernandez, M. Igartua, E. G. Arias-Salgado, F. Cortes-Ledesma, L. Sastre and R. Perona
Cell Death Differ,Jan 22, doi: 10.1038/s41418-018-0272-7

c-Met Signaling Is Essential for Mouse Adult Liver Progenitor Cells Expansion After Transforming Growth Factor-beta-Induced Epithelial-Mesenchymal Transition and Regulates Cell Phenotypic Switch
Autores: L. Almale, M. Garcia-Alvaro, A. Martinez-Palacian, M. Garcia-Bravo, N. Lazcanoiturburu, A. Addante, C. Roncero, J. Sanz, O. L. M. de la, P. Bragado, W. Mikulits, V. M. Factor, S. S. Thorgeirsson, J. I. Casal, J. C. Segovia, E. Rial, I. Fabregat, B. Herrera and A. Sanchez
Stem Cells,May 20, doi: 10.1002/stem.3038

Premature aging and cancer development in transgenic mice lacking functional CYLD
Autores: J. P. Alameda, A. Ramirez, R. A. Garcia-Fernandez, M. Navarro, A. Page, J. Segovia, R. Sanchez, C. Suarez-Cabrera, J. M. Paramio, A. Bravo, M. J. Fernandez-Aceñero and M. L. Casanova
AGING,11,127-159,pubmed: DOI: 10.18632/aging.101732

Addressing the diagnostic gaps in pyruvate kinase deficiency: Consensus recommendations on the diagnosis of pyruvate kinase deficiency
Autores: P. Bianchi, E. Fermo, B. Glader, H. Kanno, A. Agarwal, W. Barcellini, S. Eber, J. D. Hoyer, D. J. Kuter, T. M. Maia, M. D. M. Manu-Pereira, T. A. Kalfa, S. Pissard, J. C. Segovia, E. van Beers, P. G. Gallagher, D. C. Rees, R. van Wijk and t. E. R. N. i. R. H. D. with the endorsement of EuroBloodNet
Am J Hematol,Jan,94,149-161, doi: 10.1002/ajh.25325

Valencia J*, Fernández-Sevilla LM*, Fraile-Ramos A; Sacedón R, Jiménez E, Vicente A*, Varas A*. (* equal contribution). Acute lymphoblastic leukaemia cells impair dendritic cell and macrophage differentiation: role of BMP4. Cells (2019) Jul 14;8(7):722. doi: 10.3390/cells8070722 I.F: 5,66 Q1.

Muñoz JJ, Tobajas E, Juara S, Montero S, Zapata AG. FoxN1 mediates thymic cortex-medulla differentiation through modifying a developmental pattern based on epithelial tubulogenesis. Histochem Cell Biol. 2019 Dec;152(6):397-413. doi: 10.1007/s00418-019-01818-z Epub 2019 Sep 24. PMID: 31552487

2018

C León, A Cifuentes, A Valdes. Foodomics Applications. Comprehensive Analytical Chemistry V 82 (2018) Editors: Joaquim Jaumot, Carmen Bedia, Romà Tauler. Publisher: ELSEVIER. ISBN: 9780444640444 https://doi.org/10.1016/bs.coac.2018.06.008

Montero-Herradón S, García-Ceca J, Zapata AG. Altered Maturation of Medullary TEC in EphB-Deficient Thymi Is Recovered by RANK Signaling Stimulation. Front Immunol. 9:1020 (2018). doi: 10.3389/fimmu.2018.01020 IF: 5.511; Q1 (Immunology).

Muñoz JJ, García-Ceca J, Montero-Herradón S, Sánchez Del Collado B, Alfaro D, Zapata A. Can a Proper T-Cell Development Occur in an Altered Thymic Epithelium? Lessons From EphB-Deficient Thymi. Front Endocrinol (Lausanne). 9:135 (2018). doi: 10.3389/fendo.2018.00135 IF: 3.519; Q2 (Endocrinology and Metabolism).

Outcome of haematopoietic stem cell transplantation in dyskeratosis congenita. Fioredda F, Iacobelli S, Korthof ET, et al. Br J Haematol. 2018 Oct;183(1):110-118. doi: 10.1111/bjh.15495 Epub 2018 Jul 9.

Leukocyte adhesion deficiency-I: A comprehensive review of all published cases. Almarza Novoa E, Kasbekar S, Thrasher AJ, et al. J Allergy Clin Immunol Pract. 2018 Jul-Aug;6(4):1418-1420.e10. doi: 10.1016/j.jaip.2017.12.008 Epub 2018 Jan 20.

Correction of recessive dystrophic epidermolysis bullosa by homology-directed repair-mediated genome editing. Bonafont J, Mencía A, Chacón-Solano E, Srifa W, Vaidyanathan S, Romano R, García M, Hervás-Salcedo R, Ugalde L, Duarte B, Porteus MH, Del Río M, Larcher F, Murillas R. 2021. Molecular Therapy. 29(6):2008-2018.
PMID: 33609734 doi: 10.1016/j.ymthe.2021.02.019
https://www.sciencedirect.com/science/article/pii/S1525001621000861?via%3Dihub

Non-viral delivery of CRISPR–Cas9 complexes for targeted gene editing via a polymer delivery system. O’Keeffe Ahern J, Lara-Sáez I, Zhou D, Murillas R, Bonafont J, Mencía Á, García M, Manzanares D, Lynch J, Foley, R., Xu, Q., Sigen, A., Larcher, F., Wang, W. 2021. Gene Therapy 171: 207-218.
PMID: 29704747 doi: 10.1016/j.biomaterials.2018.04.031
https://www.sciencedirect.com/science/article/pii/S0142961218302862?via%3Dihub

Inhibitory Role of Growth Hormone in the Induction and Progression Phases of Collagen-Induced Arthritis
Autores: R. Villares, G. Criado, Y. Juarranz, M. Lopez-Santalla, E. M. García-Cuesta, J. M. Rodríguez-Frade, J. Leceta, P. Lucas, J. L. Pablos, C. Martínez-A, M. I. Garin, R. P. Gomariz and M. Mellado
Frontiers in Immunology, 2018 May 25,9, PMC5980961 doi: 10.3389/fimmu.2018.01165

Worldwide study of hematopoietic allogeneic stem cell transplantation in pyruvate kinase deficiency.
Autores: V. Straaten, P. Bierings, P. Bianchi, K. Akiyoshi, H. Kanno, I. B. Serra, X. Chen, E. Huang, V. Beers, S. Ekwattaanakit, T. Gungor, W. A. Kors, F. Smiers, R. Raymakers, L. Yanez, J. Sevilla, V. Solinge, C. Segovia and V. Wijk
haematologica, PMC5792292 doi: 10.3324/haematol.2017.177857

Advances in Gene Therapy for Fanconi Anemia
Autores: P. Rio, S. Navarro and J. A. Bueren
Hum Gene Ther,Oct,29,1114-1123,pubmed: 30117331 doi: 10.1089/hum.2018.124

Comparative Analysis between the In Vivo Biodistribution and Therapeutic Efficacy of Adipose-Derived Mesenchymal Stromal Cells Administered Intraperitoneally in Experimental Colitis
M. Lopez-Santalla, P. Mancheno-Corvo, A. Escolano, R. Menta, O. Delarosa, J. M. Redondo, J. A. Bueren, W. Dalemans, E. Lombardo and M. I. Garin
Int J Mol Sci,Jun 23,19,PMC6073850 doi: 10.3390/ijms19071853

Efficient Non-viral Gene Delivery into Human Hematopoietic Stem Cells by Minicircle Sleeping Beauty Transposon Vectors
Author: M. Holstein, C. Mesa-Nunez, C. Miskey, E. Almarza, V. Poletti, M. Schmeer, E. Grueso, J. C. Ordonez Flores, D. Kobelt, W. Walther, M. K. Aneja, J. Geiger, H. B. Bonig, Z. Izsvak, M. Schleef, C. Rudolph, F. Mavilio, J. A. Bueren, G. Guenechea and Z. Ivics
Mol Ther,Apr 4,26,1137-1153,pubmed: PMC6079369 doi: 10.1016/j.ymthe.2018.01.012

Leukocyte adhesion deficiency-I: A comprehensive review of all published cases
Author: E. Almarza Novoa, S. Kasbekar, A. J. Thrasher, D. B. Kohn, J. Sevilla, T. Nguyen, J. D. Schwartz and J. A. Bueren J Allergy Clin Immunol Pract,Jul - Aug,6,1418-1420 e10,pubmed: doi: 10.1016/j.jaip.2017.12.008

Improved Hematopoietic Gene Therapy in a Mouse Model of Fanconi Anemia Mediated by Mesenchymal Stromal Cells.
Autores: Fernández-García M, Luisa Lamana M, Hernando-Rodríguez M, Sánchez-Domínguez R, Bueren J, Yáñez R.
Hum Gene Ther; 2018 Mar. - PubMed; PMID: 28816065 Doi: 10.1089/hum.2017.076

Molecular Evidence of Genome Editing in a Mouse Model of Immunodeficiency
Autores: H. H. Abdul-Razak, C. J. Rocca, S. J. Howe, M. E. Alonso-Ferrero, J. Wang, R. Gabriel, C. C. Bartholomae, C. H. V. Gan, M. I. Garín, A. Roberts, M. P. Blundell, V. Prakash, F. J. Molina-Estevez, J. Pantoglou, G. Guenechea, M. C. Holmes, P. D. Gregory, C. Kinnon, C. von Kalle, M. Schmidt, J. A. Bueren, A. J. Thrasher and R. J. Yáñez-Muñoz
Scientific Reports,8,doi: 10.1038/s41598-018-26439-9

Hematopoietic Stem and Progenitor Cell Mobilization and Collection for Patients Diagnosed with Osteopetrosis and Hurler Syndrome. Sevilla J, Iriondo J, Sebastian E, et al. Hum Gene Ther. 2022 Feb;33(3-4):213-214. doi: 10.1089/hum.2022.29197.jse

Who should be eligible for gene therapy clinical trials in red blood cell pyruvate kinase deficiency (PKD)?: Toward an expanded definition of severe PKD. Schwartz JD, Barcellini W, Grace RF, et al. Am J Hematol. 2022 Mar 1;97(3):E120-E125. doi: 10.1002/ajh.26458 Epub 2022 Jan 24.

Next-generation Sequencing in Bone Marrow Failure Syndromes and Isolated Cytopenias: Experience of the Spanish Network on Bone Marrow Failure Syndromes. Gálvez E, Vallespín E, Arias-Salgado EG, et al. Hemasphere. 2021 Mar 9;5(4):e539. doi: 10.1097/HS9.0000000000000539 eCollection 2021 Apr.

Haplo-identical or mismatched unrelated donor hematopoietic cell transplantation for Fanconi anemia: Results from the Severe Aplastic Anemia Working Party of the EBMT. Zubicaray J, Pagliara D, Sevilla J, et al. Am J Hematol. 2021 May 1;96(5):571-579. doi: 10.1002/ajh.26135 Epub 2021 Mar 4.

Plerixafor-based mobilization in pediatric healthy donors with unfavorable donor/recipient body weight ratio resulted in a better CD34+ collection yield: A retrospective analysis. Zubicaray J, Galvez E, Sebastian E, et al. J Clin Apher. 2021 Feb;36(1):78-86. doi: 10.1002/jca.21844 Epub 2020 Oct 20.

Emapalumab in Children with Primary Hemophagocytic Lymphohistiocytosis. Locatelli F, Jordan MB, Allen C, et al. N Engl J Med. 2020 May 7;382(19):1811-1822. doi: 10.1056/NEJMoa1911326

Optimised molecular genetic diagnostics of Fanconi anaemia by whole exome sequencing and functional studies. Bogliolo M, Pujol R, Aza-Carmona M, et al. J Med Genet. 2020 Apr;57(4):258-268. doi: 10.1136/jmedgenet-2019-106249. Epub 2019 Oct 5.
Successful engraftment of gene-corrected hematopoietic stem cells in non-conditioned patients with Fanconi anemia. Río P, Navarro S, Wang W, et al. Nat Med. 2019 Sep;25(9):1396-1401. doi: 10.1038/s41591-019-0550-z Epub 2019 Sep 9.

Therapeutic gene editing in CD34+ hematopoietic progenitors from Fanconi anemia patients. Diez B, Genovese P, Roman-Rodriguez FJ, et al. EMBO Mol Med. 2017 Nov;9(11):1574-1588. doi: 10.15252/emmm.201707540

Engraftment and in vivo proliferation advantage of gene-corrected mobilized CD34+ cells from Fanconi anemia patients. Río P, Navarro S, Guenechea G, et al. Blood. 2017 Sep 28;130(13):1535-1542. doi: 10.1182/blood-2017-03-774174 Epub 2017 Aug 11.

Donor age matters in T-cell depleted haploidentical hematopoietic stem cell transplantation in pediatric patients: Faster immune reconstitution using younger donors. González-Vicent M, Molina B, Deltoro N, et al. Leuk Res. 2017 Jun;57:60-64. doi: 10.1016/j.leukres.2017.03.001 Epub 2017 Mar 4.

Lessons Learned from Two Decades of Clinical Trial Experience in Gene Therapy for Fanconi Anemia. Adair JE, Sevilla J, Heredia CD, et al. Curr Gene Ther. 2017;16(5):338-348. doi: 10.2174/1566523217666170119113029

Non-viral delivery of CRISPR–Cas9 complexes for targeted gene editing via a polymer delivery system. O’Keeffe Ahern J, Lara-Sáez I, Zhou D, Murillas R, Bonafont J, Mencía Á, García M, Manzanares D, Lynch J, Foley, R., Xu, Q., Sigen, A., Larcher, F., Wang, W. 2021. Gene Therapy 171: 207-218.
PMID: 29704747 doi: 10.1016/j.biomaterials.2018.04.031
https://www.sciencedirect.com/science/article/pii/S0142961218302862?via%3Dihub

Immunotherapeutic effect of adenovirus encoding antimicrobial peptides in experimental pulmonary tuberculosis. Ramos-Espinosa O, Mata-Espinosa D, Francisco-Cruz A, López-Torres MO, Hernández-Bazán S, Barrios-Payán J, Marquina-Castillo B, Carretero M, Del Río M, Hernández-Pando R. 2021. Journal of Leukocyte Biology. 110(5):951-963
PMID: 33682193 doi: 10.1002/JLB.4MA0920-627R
https://jlb.onlinelibrary.wiley.com/doi/10.1002/JLB.4MA0920-627R

Epidermolysis Bullosa in Spain: Observational Study of a Cohort of Patients Treated in a National Referral Center. Maseda Pedrero R, Quintana Castanedo L, Pérez Conde I, Jiménez González M, Escámez Toledano MJ, de Lucas Laguna R. 2021. Actas Dermo-Sifiliográficas. 112:781-793
PMID: 33984313. doi: 10.1016/j.ad.2021.04.006
https://www.sciencedirect.com/science/article/pii/S0001731021001769?via%3Dihub

Capítulos de libro

Libro: Quílez C, de Aranda Izuzquiza G, García M, López V, Montero A, Valencia L, Velasco D. Bioprinting for Skin. 2020. In: Crook J (eds) 3D Bioprinting. Methods in Molecular Biology. Humana, New York, NY. Vol 2140: 263 pp. ISBN 978-1-0716-0519-6.
PMID: 32207115 doi: 10.1007/978-1-0716-0520-2_14
https://link.springer.com/protocol/10.1007%2F978-1-0716-0520-2_14

C León, A Cifuentes, A Valdes. Foodomics Applications. Comprehensive Analytical Chemistry V 82 (2018) Editors: Joaquim Jaumot, Carmen Bedia, Romà Tauler. Publisher: ELSEVIER. ISBN: 9780444640444

Alfaro D, Zapata A. Eph/Ephrin-mediated stimulation of human bone marrow mesenchymal stromal cells correlates with changes in cell adherence and increased cell death. Stem Cell Res Ther. 2018 Jun 26;9(1):172. doi: 10.1186/s13287-018-0912-3 IF 4.963 (2017). Q1 (Medicine, Research & Experimental).

Alfaro D, Rodríguez-Sosa MR, Zapata AG. Eph/ephrin Signaling and Biology of Mesenchymal Stromal/Stem Cells. J Clin Med. 2020 Jan 22;9(2):310. doi: 10.3390/jcm9020310 PMID: 31979096.

García-Ceca J, Montero-Herradón S, Zapata AG. Thymus aging in mice deficient in either EphB2 or EphB3, two master regulators of thymic epithelium development. Dev Dyn. 2020 Oct; 249(10):1243-1258. doi: 10.1002/dvdy.212 Epub 2020 Jun 25. PMID: 32506584

García-Ceca J, Montero-Herradón S, Zapata AG. Intrathymic Selection and Defects in the Thymic Epithelial Cell Development. Cells. 2020 Oct 2;9(10):2226. doi: 10.3390/cells9102226 PMID: 33023072.

García-Bernal D, García-Arranz M, Yáñez RM, Hervás-Salcedo R, Cortés A, Fernández-García M, Hernando-Rodríguez M, Quintana-Bustamante Ó, Bueren JA, García-Olmo D, Moraleda JM, Segovia JC, Zapata AG. The Current Status of Mesenchymal Stromal Cells: Controversies, Unresolved Issues and Some Promising Solutions to Improve Their Therapeutic Efficacy. Front Cell Dev Biol. 2021 Mar 16;9:650664. doi: 10.3389/fcell.2021.650664 eCollection 2021. PMID: 33796536. I.F. (2019): 5.186 Q1.

Montero-Herradón S, García-Ceca J, Zapata AG. How Many Thymic Epithelial Cells Are Necessary for a Proper Maturation of Thymocytes? Front Immunol. 2021 Mar 8;12:618216. doi: 10.3389/fimmu.2021.618216 eCollection 2021. PMID: 33763065. Review.

Montero-Herradón S, Zapata AG. Delayed maturation of thymic epithelium in mice with specific deletion of β-catenin gene in FoxN1 positive cells. Histochem Cell Biol. 2021 Jul 12. doi: 10.1007/s00418-021-02012-w Online ahead of print. PMID: 34254201

Fernández-Sevilla LM, Belenguer G, Martí-Prado B, Ortiz-Sánchez P, Ramírez M, Varas A, Fariñas I, Vicente Á. Acute lymphoblastic leukemia cells are able to infiltrate the brain subventricular zone stem cell niche and impair neurogenesis. Haematologica. 2022 Apr 1;107(4):1004-1007. doi: 10.3324/haematol.2021.279383 PMID: 35045691

Muñoz JJ, Zapata AG. Epithelial development based on a branching morphogenesis programme: The especial condition of thymic epithelium. In “Histology”. IntechOpen. pp:19-45 (2018). DOI: 10.5772/intechopen.81193

Muñoz JJ, Zapata AG. Thymus ontogeny and development. In “Thymus Transcriptome and Cell Biology”. GA Passos, ed. Springer, pp: 19-34

Zapata, A.G. Inmunología comparada. Inmunología (Biología y patología del sistema inmunitario). Editorial Panamericana. Sept. 2020.

Patentes

Título: Pyruvate kinase deficiency (PKD) gene editing treatment method
Inventores: JC. Segovia Sanz, S. Fañanás Baquero, O. Quintana Bustamante, M. Porteus
Referencia: EP20382568.2
Titular: CIEMAT-CIBERER / IIS-FJD and Stanford University

Título: Gene editing for the treatment of epidermolysis bullosa.
Referencia: PCT/EP2021/051224, WO/2021/148483
Fecha de publicación: 29/07/2021
Inventores: Jose Bonafont Arago, Fernando Larcher Laguzzi, Rodolfo Murillas Angoiti, Marcela Andrea Del Río Nechaevsky, Ángeles Mecía Rodríguez, Marta García, María José Escámez Toledano, Mathew Porteus.

Título: Aptámeros agonistas del receptor FPR2 y usos de los mismos
Referencia: PCT/ES2020/070378, WO/2020/249841
Fecha de publicación: 17/12/2020
Inventores: Marta Carretero Trillo, María del Carmen de Arriba Pérez, Marcela Andrea del Río Nechaevsky, Gerónimo Fernández Gómez-Chacón, Víctor Manuel González Muñoz, Rebeca Carrión Marchante, Elena Martín Palma.

Título: Inhibidores de tgf-ß1 y productores de endoglina para su uso en el tratamiento de epidermólisis bullosa
Referencia: PCT/ES2019/070757
Fecha de publicación: 07/11/2019
Inventores: Marcela Andrea del Rio Nechaevsky, Adela María García Martín, Marta García Díez, José María Sánchez-Puelles González-Carvajal, Luisa María Botella Cubells, Tania Aguado Sánchez, Fernando Larcher Laguzzi, Marta Carretero Trillo.

Utilización de células madre mesenquimales en la preparación de una composición para Terapia”.
Autores: de la Cueva T, Rodriguez R, Masit M, Rubio R, Menéndez P, Zapata AG, Ramírez M, Arriero M, Gª Castro J.
Nº solicitud: P200930033

Título: Improvements for performing and facilitating the recovery after hematopoietic stem cell transplantation
Inventores: O. Quintana, J. C. Segovia, J. Bueren
Referencia: PCT/EP2019/079945
Titular: CIEMAT/CIBERER/IIS-FJD

Título: Lentiviral vectors for delivery of PKLR to treat protein kinase deficiency
Inventores: J. Bueren, S. Navarro, J. C. Segovia, M. García Gómez, N. Meza, M. García Bravo
Referencia: PCT/US2018/056136
Titular: CIEMAT/CIBERER/IIS-FJD

Título: Methods for gene modification of hematopoietic cells
Inventores: J. Bueren, J. C. Segovia, P. Rio Galdo, S. Navarro Ordóñez, E. Almarza Novoa, O. Quintana Bustamante, C. Mesa
Referencia: PCT/US2019/044237
Titular: CIEMAT/CIBERER/IIS-FJD/Rocket Pharma

Medicamentos huérfanos

Título: Autologous skin equivalent graft composed of keratinocytes and fibroblasts genetically corrected by CRISPR/Cas9-mediated excision of mutation-carrying COL7A1 exon 80.
Referencia: EMA/OD/0000013899
Fecha de publicación: 28/02/2020
Inventores: Fernando Larcher Laguzzi, Rodolfo Murillas Angoiti, Ángeles Mecía Rodríguez, Jose Bonafont Arago, María José Escámez Toledano, Álvaro Meana Infiesta, Sara María Gómez Llames, Silvia Modamio Hoybjor, Lucía Martínez Santamaría, Marta García Díez, Marcela Andrea del Río Nechaevsky