Publications

Publications HTG-CIEMAT

  1. Tolar J, Becker PS, Clapp DW, Hanenberg H, de Heredia CD, Kiem HP, Navarro S, Qasba P, Río P, Schmidt M, Sevilla J, Verhoeyen E, Thrasher AJ, Bueren J. Gene Therapy for Fanconi Anemia: One Step Closer to the Clinic. Hum Gene Ther (2012).
  2. Río P, Agirre X, Garate L, Baños R, Álvarez L, San José-Enériz, E, Badell I,  Casado JA, Garín M, Prósper F and Bueren JA. Downregulated Expression of hsa-miR-181c in Fanconi Anemia Patients: Implications in TNF Regulation and in the Proliferation of Hematopoietic Progenitor Cells. Blood (2012).
  3. Valeri A, Río P,  Agirre X, Prosper F and  Bueren JA. Unraveling the Role of FANCD2 in Chronic Myeloid Leukemia. (Letter) Leukemia (2012).
  4. Cuesta-Domínguez Á, Ortega M, Ormazábal C, Santos-Roncero M, Galán-Díez M, Steegmann JL, Figuera Á, Arranz E, Vizmanos JL, Bueren JA, Río P, Fernández-Ruiz E. Transforming and tumorigenic activity of JAK2 by fusion to BCR: molecular mechanisms of action of a novel BCR-JAK2 tyrosine-kinase. PLoS One. (2012). 
  5. Oviedo A, Yañez R, Colmenero I, Aldea M, Rubio A, Bueren JA, Lamana ML. Reduced efficacy of mesenchymal stromal cells in preventing graft-vs-host disease in an in vivo model of haploidentical bone marrow transplant with leukemia. Cell Transplant. 2012. 
  6. Zita Garate, Brian R. Davis, Oscar Quintana-Bustamante, and Jose C. Segovia. New Frontier in Regenerative Medicine: Site-Specific Gene Correction in Patient-Specific Induced Pluripotent Stem Cells. Human Gene Therapy  (2013). 
  7. Massimo Bogliolo, Beatrice Schuster, Chantal Stoepker,Burak Derkunt, Yan Su, Anja Raams,Juan P. Trujillo, Jordi Minguillon, Mar¿a J. Ram¿rez, Roser Pujol, Jose A. Casado, Roc¿o Banos,Paula Rio, Kerstin Knies, Sheila Zuniga,Javier Ben¿tez, Juan A. Bueren, Nicolaas G.J. Jaspers, Orlando D. Scharer, Johan P. de Winter, Detlev Schindler, and Jordi Surralles. Mutations in ERCC4, Encoding the DNA-Repair Endonuclease XPF, Cause Fanconi Anemia. The American Society of Human Genetics. (2013). 
  8. Molina-Estevez FJ, Lozano ML, Navarro S, Torres Y, Grabundzija I, Ivics Z, Samper E, Bueren JA, Guenechea G. Brief report: Impaired cell reprogramming in nonhomologous end joining deficient cells. Stem Cells (2013). 
  9. Navarro S, Moleiro V, Molina-Estevez FJ, Lozano ML, Chinchon R, Almarza E, Quintana-Bustamante O, Mostoslavsky G, Maetzig T, Galla M, Heinz N, Schiedlmeier B, Torres Y, Modlich U, Samper E, Río P, Segovia JC, Raya A, Güenechea G, Izpisua-Belmonte JC, Bueren JA. Generation of iPSCs from genetically corrected Brca2 hypomorphic cells: implications in cells reprogramming and stem cell therapy. Stem Cells (2014). 
  10. Rio P, Baños R, Lombardo A, Quintana-Bustamante O, Alvarez L, Garate Z, Genovese P, Almarza E, Valeri A, Díez B, Navarro S, Torres Y, Trujillo JP, Murillas R, Segovia JC, Samper E, Surralles J, Gregory PD, Holmes MC, Naldini L, Bueren JA. Targeted gene therapy and cell reprogramming in Fanconi anemia. EMBO Mol Med (2014).
  11. Leon-Rico D, Aldea M, Sanchez R, Segovia JC, Weiss LA, Hidalgo A, Bueren JA, Almarza E. Brief report: Reduced expression of CD18 leads to the in vivo expansion of hematopoietic stem cells in mouse bone marrow. Stem Cells (2014).
  12. Quintana-Bustamante, O, Segovia JC. Generation of patient-specific induced pluripotent stem cell from peripheral blood mononuclear cells by sendai reprogramming vectors. Methods Mol Biol (2014).
  13. Groult H, Ruiz-Cabello J, Pellico J, Lechuga-Vieco AV, Bhavesh R, Zamai M,Almarza E, Martín-Padura I, Cantelar E, Martínez-Alcázar MP, Herranz F. Parallel Multifunctionalization of Nanoparticles: A One-Step Modular Approach for in Vivo Imaging. Bioconjugate Chemistry. (2014).
  14. Saiz-Ladera, C.; Lara, M. F.; Garin, M.; Ruiz, S.; Santos, M.; Lorz, C.; Garcia-Escudero, R.; Martinez-Fernandez, M.; Bravo, A.; Fernandez-Capetillo, O.; Segrelles, C.; Paramio, J. M. p21 suppresses inflammation and tumorigenesis on pRB-deficient stratified epithelia. Oncogene. (2014).
  15. Cuesta-Domínguez Á1, León-Rico D, Álvarez L, Diez-Cabezas B, Bodega-Mayor I, Baños R, Martín-Rey MÁ, Santos-Roncero M, Gaspar ML, Martín-Acosta P, Almarza E, Bueren J, Río P, Fernández-Ruiz E. BCR-JAK2 drives a myeloproliferative neoplasm in transplanted mice. J Pathol (2015).
  16. León-Rico D, Fernández-García M, Aldea M, Sánchez R, Peces-Barba M, Martinez-Palacio J, Yáñez RM, Almarza E. Comparison of haematopoietic stem cell engraftment through the retro-orbital venous sinus and the lateral vein: alternative routes for bone marrow transplantation in mice. Lab Anim (2015).

Publications BIOC-ISCIII

  1. Rodríguez-Milla MA, Mirones J, Mariñas-Pardo L, Melen GJ, Cubillo I, Ramírez M y García-Castro J. Enrichment of neural-related genes in human mesenchymal stem cells from neuroblastoma patients. Int J Mol Med. (2012).
  2. R Rubio*, A Abarrategi*, J  Garcia-Castro*, L Martinez-Cruzado, C Suarez3, J Tornin, L Santos, A Astudillo, I Colmenero, F Mulero, M Rosu-Myles, P Menendez, R Rodriguez. Bone environment is essential for osteosarcoma development from transformed mesenchymal stem cells. Stem Cells (2014).
  3. Á Vicente López, MN Vázquez García, GJ Melen, A Entrena Martínez, I Cubillo Moreno, J García-Castro, M Ramírez Orellana, AG Zapata González. Mesenchymal stromal cells derived from the bone marrow of acute lymphoblastic leukemia patients show altered BMP4 production: Correlations with the course of disease. Plos ONE (2014).
  4. Abarrategi A, Perez-Tavarez R, Rodriguez-Milla MA, Cubillo I, Mulero F, Alfranca A, Lopez-Lacomba JL, García-Castro J. In Vivo Ectopic Implantation Model to Assess Human Mesenchymal Progenitor Cell Potential. Stem Cell Rev. (2013).
  5. Isabel Mirones, Inmaculada de Prada, Ana M. Gómez, Alfonso Luque, Roberto Martín, M. Ángeles Pérez-Jiménez, Luis Madero, Javier García-Castro, Manuel Ramírez. A Role for the CXCR3/CXCL10 Axis in Rasmussen Encephalitis Pediatric Neurology  (2013).
  6. Agustín F. Fernandez, Gustavo F. Bayón, Rocío G. Urdinguio, Estela G. Toraño, Sandra Petrus, Cecilia Ferrero, Pablo Martinez-Camblor, Isabel Cubillo, Javier García-Castro, Jesús Delgado-Calle, José A. Riancho, Corrado Fagnani, Emanuela Medda, Virgilia Toccaceli, Sebastián Moran, Manel Esteller, Lorenza Nistico, María A. Stazi, Mario F. Fraga. H3K4me1 marks regions hypomethylated during aging in human stem and differentiated cells. Genome Research (2014).
  7. Cussó L, Mirones I, Peña-Zalbidea S, García-Vázquez V, García-Castro J, Desco M. Combination of Single-Photon Emission Computed Tomography and Magnetic Resonance Imaging to Track 111In-Oxine-Labeled Human Mesenchymal Stem Cells in Neuroblastoma-Bearing Mice. Molecular Imaging (2014).
  8. Isabel Mirones, Miguel Ángel Rodríguez*, Isabel Cubillo, Luis Mariñas-Pardo, Teresa de la Cueva, Agustín Zapata, Carlos González, Manuel Ramírez, Javier García-Castro.   Dopamine mobilizes mesenchymal progenitor cells into peripheral blood through D2-class receptors and their PI3K/AKT pathway. Stem Cells (2014).
  9. Luis Antonio Mariñas-Pardo, Isabel Mirones-Aguilar, Oscar Amor-Carro, Rebeca Fraga-Iriso, Beatriz Lema-Costa, Isabel Cubillo-Moreno, Miguel Angel-Rodriguez Milla, Javier García-Castro*, David Ramos-Barbón*. Adipose-derived mesenchymal stem cells regulate airway contractile tissue remodeling in experimental asthma. Allergy (2014). 
  10. Abarrategi A, Perez-Tavarez R, Rodriguez-Milla MA, Cubillo I, Mulero F, Alfranca A, Lopez-Lacomba JL, García-Castro J. In Vivo Ectopic Implantation Model to Assess Human Mesenchymal Progenitor Cell Potential. Stem Cell Rev. (2013).
  11. Isabel Mirones, Inmaculada de Prada, Ana M. Gómez, Alfonso Luque, Roberto Martín, M. Ángeles Pérez-Jiménez, Luis Madero, Javier García-Castro, Manuel Ramírez. A Role for the CXCR3/CXCL10 Axis in Rasmussen Encephalitis. Pediatric Neurology (2013).

Publications CNIC/CNB

  1. JC. Estrada, C. Albo, A. Benguría, A. Dopazo, L. Carrera-Quintanar, Lucia Morgado,  E. Roche, A. Bernad *and E. Samper*. (*) Corresponding authors. Culture of human mesenchymal stem cells at low oxygen tensión improves grouth and genetic stability by activating glycolysis.  Cell Death Differ. 19:743-55 (2012).
  2. JG. Casado, G. Gómez-Mauricio, V. Alvarez, J. Mijares, S, Martínez-Caballero, A. Bernad, F.M. Sánchez-Margallo. Comparative phenotypic and molecular characterization of porcine mesenchymal stem cells from different sources for translational studies in a large animal model. Vet. Immunol. Immunopathol. 147:104-12. (2012).
  3. D. Horna, JC. Ramírez, A. Cifuentes, S. Borros-Gómez, A. Bernad and MA. González. Efficient cell reprogramming using bioengineered surfaces. Adv Healthc Mater. 1(2):177-82 (2012).
  4. MA. González and A. Bernad. Characteristics of adult stem cells. Adv. Exp. Med. Biol. 741:103-20.2012.
  5. Lara D, Estrada JC, Izarra A, Albo C, Moscoco I, Samper E, Moncayo J, Solano A, Bernad A*  and  Díez-Juan A*. Complement anaphylatoxins C3a and C5a induce a failing regenerative program in cardiac resident cells. Evidence of a role for cardiac resident stem cells other than cardiomyocyte renewal. SpringerPlus 1:63 doi:10.1186/2193-1801-1-63.2012.
  6. Daniel Lucas, José M. Delgado-García, Beatriz Escudero, Carmen Albo, María del Mar, Arroyo-Jiménez, Enrique Samper, Luis Blanco, Alfonso Fairén, A. Bernad* Agnès Gruart * (*) Corresponding authors. Increased learning and brain long-term potentiation in aged mice lacking DNA polymerase m. PLoS ONE 8(1):e53243.2013.2013. (2013).
  7. Moscoso I, Naiara Tejados, Olga Barreiro, Pilar Sepúlveda, Alberto Izarra, Enrique Calvo, Akaitz Dorronsoro, Juan Manuel Salcedo, Rafael Sádaba, Antonio Díez-Juan, César Trigueros and Antonio Bernad. Podocalyxin-like protein 1 is a relevant marker for human c-kitpos cardiac stem cells.  Journal of Tissue Engineering and Regenerative Medicine. doi: 10.1002/term.1795 (2013).
  8. Estrada JC, Y. Torres, A. Benguría, A. Dopazo, E. Roche, L. Carrera-Quintanar, R. Acín-Pérez1, JA. Enríquez, R. Torres,  JC. Ramírez, E. Samper* and A. Bernad* (2013) Human mesenchymal stem cell replicative senescence and oxidative stress are closely linked to aneuploidy. Cell Death & Ther. 4:e691.               
  9. Sepúlveda JC, María Tomé, María Eugenia Fernández, Mario Delgado, Judith Campisi, Antonio Bernad*, Manuel A. González*. Cell senescence abrogates the therapeutic potential of human mesenchymal stem cells in the lethal endotoxemia model. Stem Cells, 32:1865-77. doi: 10.1002/stem.1654 (2013).
  10. Tomé M, Juan Carlos Sepúlveda, Mario Delgado, José A. Andrades, Judith Campisi, Manuel A. González* & Antonio Bernad*.. miR-335 correlates with senescence/aging in human mesenchymal stem cells and inhibits their therapeutic actions through inhibition of AP-1 activity. Stem Cells32: 2229-44. (2014).
  11. Escudero B, Lucas D, Albo C, Dhup S, Bacher JW, Sánchez-Muñoz A, Fernández M, Rivera-Torres J, Carmona RM, Fuster E, Carreiro C, Bernad R, González MA, Andrés V, Blanco L, Roche E, Fabregat I, Samper E, Bernad A. Polm deficiency increases resistance to oxidative damage and delays liver aging. PLoS One. (2014).
  12. J In JG, Striz AC, Bernad A, Tuma PL. Serine/threonine kinase 16 and MAL2 regulate constitutive secretion of soluble cargo in hepatic cells.  Biochem J. 463:201-13. (2014).
  13. Izarra A, Isabel Moscoso, Elif Levent, Susana Cañón, Inmaculada Cerrada, Antonio Díez-Juan, Vanessa Blanca, Iván J Núñez-Gil, Iñigo Valiente, Amparo Ruíz-Sauri, Pilar Sepúlveda, Malte Tiburcy, Wolfram-H. Zimmermann & Antonio Bernad. miR-133a enhances the protective capacity of cardiac progenitors cells after myocardial. Stem Cell Reports 3: 1-14. (2014) .
  14. Izarra A, Isabel Moscoso, Candelas Carreiro, Dolors Fondevila, Juan Martín-Caballero, Vanessa Blanca, Iñigo Valiente, Antonio Díez-Juan and Antonio Bernad. "miRNA-1 and miRNA-133a are involved in early commitment of pluripotent stem cells and demonstrate antagonistic roles in regulation of cardiac differentiation"  Journal of Tissue Engineering and Regenerative Medicine. Preview access. (2104).
  15. Cruz, FM, David Sanz-Rosa, Marta Roche-Molina, Jaime García-Prieto, Jose Manuel Garcia-Ruiz, Gonzalo Pizarro, Jesús Jiménez-Borreguero, Miguel Torres, Antonio Bernad, Jesús Ruiz-Cabello, Valentin Fuster, Borja Ibanez, Juan Bernal. Exercise triggers arrhythmogenic right ventricular cardiomyopathy phenotype in mice expressing a disease-causing mutated version of human plakophilin-2. The Journal of the American College of Cardiology,  in press. (2014).
  16. Gomes-Alves, P, Margarida Serra, Catarina Brito, Luis R-Borlado, Juan A. López, Jesús Vázquez, Manuel J.T. Carrondo, António Bernad, Paula M. Alves.. Exploring analytical proteomics platforms towards the definition of human Cardiac Stem Cells receptome.  Proteomics, in press. (2014).

Publications FIBHUNJS

  1. Chillón MC, GómezCasares MT, LópezJorge CE, RodriguezMedina C, Molines A, Sarasquete ME, Alcoceba M, Miguel JD, Bueno C, Montes R, Ramos F, Rodríguez JN, Giraldo P,Ramírez M, GarcíaDelgadoR, Fuster JL, GonzálezDíaz M,Menendez P. (2012). Prognostic significance of FLT3 mutational status and expression levels in MLLAF4+ and MLLgermline acute lymphoblastic leukemia. Leukemia. 
  2. Pérez-Martínez A1, González-Vicent M, Valentín J, Aleo E, Lassaletta A, Sevilla J, Vicario JL, Ramírez M, Díaz MA. Early evaluation of immune reconstitution following allogeneic CD3/CD19-depleted grafts from alternative donors in childhood acute leukemia. Bone Marrow Transplant.  (2012).
  3. Ramírez M, GarcíaCastro. Mesenchymal Stem Cells for the Treatment of Cancer. Therapeutic Applications in Disease and Injury. Online ISBN. 9789400729933. Publisher Springer Netherlands.  (2012).
  4. Cantarín-Extremera V1, González-Gutiérrez-Solana L, Ramírez-Orellana M, López-Marín L, Duat-Rodríguez A, Ruíz-Falcó-Rojas ML. Immune-mediated mechanisms in the pathogenesis of Hopkins syndrome. Pediatric Neurology. (2012). 
  5. Fiuza-Luces C1, González-Murillo A, Soares-Miranda L, Martínez Palacio J, Colmenero I, Casco F, Melén G, Morán M, Lucia A, Ramírez M. Effects of exercise interventions in graft-versus-host disease models.  Cell Transplant. (2013).
  6. Martínez-Laperche C1, Gómez-García AM, Lassaletta Á, Moscardó C, Vivanco JL, Molina J, Fuster JL, Couselo JM, de Toledo JS, Bureo E, Madero L, Ramírez M.Martínez-Laperche C1, Gómez-García AM, Lassaletta Á, Moscardó C, Vivanco JL, Molina J, Fuster JL, Couselo JM, de Toledo JS, Bureo E, Madero L, Ramírez M. Detection of occult cerebrospinal fluid involvement during maintenance therapy identifies a group of children with acute lymphoblastic leukemia at high risk for relapse. Am J Hematol.  (2013).
  7. Sevilla J, Guillén M, Castillo A, Prudencio M, González-Vicent M, Lassaletta Á, Cormenzana M, Ramírez M, Pérez-Martínez A, Madero L, Díaz-Pérez MÁ. Defining "poor mobilizer" in pediatric patients who need an autologous peripheral blood progenitor cell transplantation. Cytotherapy.  (2013).
  8. Fiuza-Luces C, Soares-Miranda L, González-Murillo A, Palacio JM, Colmenero I, Casco F, Melén G, Morán M, Ramírez M, Lucía A. Benefits of adding an exercise intervention to conventional immunosuppression in chronic graft versus host disease: insights from a murine model. Medicine & Science in Sports & Exercise. (2013). 
  9. Mirones I, de Prada I, Gómez AM, Luque A, Martín R, Pérez-Jiménez MA, Madero L, García-Castro J, Ramírez M. A role for the CXCR3/CXCL10 axis in Rasmussen encephalitis. Pediatric Neurology.  (2013). 
  10. Ruiz-Hernández E, Hess M, Melen GJ, Theek B, Talelli M, Shi Y, Ozbakir B, Teunissen EA, Ramírez M, Moeckel D, Kiessling F, Storm G, Scheeren AW, Hennik WWE, Szalay AA, Stritzker J, Lammers T. PEG-pHPMAm-based polymeric micelles loaded with doxorubicin-prodrugs in combination antitumor therapy with oncolytic vaccinia viruses. Polym Chem.  (2014).
  11. Carceller F, Aleu A, Casasco A, Guimaraens L, López-Pino MA, Madero L, Ramírez M. Superselective Intracerebral Catheterization for Administration of Oncolytic Virotherapy in a Case of Diffuse Intrinsic Pontine Glioma. J Pediatr Hematol Oncol. (2014). 
  12. Fiuza-Luces C, Delmiro A, Soares-Miranda L, González-Murillo A, Martínez-Palacios J, Ramírez M, Lucia A, Morán M. Exercise training can induce cardiac autophagy at end-stage chronic conditions: Insights from a graft-versus-host-disease mouse model. Brain Behav Immun.  (2014).
  13. Vicente-López A, Vázquez-García MN, Melen GJ, Entrena-Martínez A, Cubillo Moreno I, García-Castro J, Ramírez M, Zapata AG. Mesenchymal Stromal Cells Derived from the Bone Marrow of Acute Lymphoblastic Leukemia Patients Show Altered BMP4 Production: Correlations with the Course of Disease. PLoS ONE.  (2014). 
  14. Mirones I, Rodríguez MA, Cubillo I, Mariñas-Pardo L, de la Cueva T, Zapata A, González C, Ramírez M, García-Castro J. Dopamine mobilizes mesenchymal progenitor cells through D2-class receptors and their PI3K/AKT pathway. Stem Cells. (2014). 
  15. Baeza A, Guisasola E, Torres-Pardo A, González-Calbet JM, Melen GJ, Ramírez M, Vallet-Regí M. Hybrid enzyme-polymeric capsules/mesoporous silica nanodevice for in situ cytotoxic agent generation. Advanced Functional Materials. (2014). 
  16. Robson NC, Hidalgo L, McAlpine T, Wei H, Martínez VG, Entrena A, Melen GJ, MacDonald AS, Phythian-Adams A, Sacedón R, Maraskovsky E, Cebon J, Ramírez M, Vicente A, Varas A. Optimal Effector Functions in Human Natural Killer Cells Rely upon Autocrine Bone Morphogenetic Protein Signaling. Cancer Res. (2014). 
  17. García-Salido A, Oñoro G, Melen GJ, Gómez-Piña V, Serrano-González A, Ramírez-Orellana M, Casado-Flores J. Serum sRAGE as a Potential Biomarker for Pediatric Bronchiolitis: A Pilot Study. Lung. (2014).

Publications HGUGM

  1. Díez Villanueva P, Sanz-Ruiz R, Núñez García A, Fernández Santos ME, Sánchez PL, Fernández-Avilés F. Functional multipotency of stem cells: what do we need from them in the heart? Stem Cells International. (2012).
  2. Ricardo Sanz-Ruiz, Alberto Núñez-García, Enrique Gutiérrez-Ibañes, Adolfo Villa-Arranz, María Eugenia Fernández-Santos, Pedro L. Sánchez-Fernández y Francisco Fernández-Avilés. Resultados clínicos de las técnicas regenerativas en medicina cardiovascular.  Clinical Trials in Cardiovascular Regenerative Medicine. (2013).
  3. Juan Carlos Sepúlveda, María Tomé, María Eugenia Fernández, Mario Delgado, Judith Campisi, Antonio Bernad, Manuel A. González. Cell senescence abrogates the therapeutic potential of human mesenchymal stem cells in the lethal endotoxemia model. Stem Cells. (2014).
  4. Perin EC, Sanz-Ruiz R, Sánchez PL, Lasso J, Pérez-Cano R, Alonso-Farto JC, Pérez-David E, Fernández-Santos ME, Serruys PW, Duckers HJ, Kastrup J, Chamuleau S, Zheng Y, Silva GV, Willerson JT, Fernández-Avilés F. Adipose-derived regenerative cells in patients with ischemic cardiomyopathy: The PRECISE Trial. Am Heart J.  (2014).

Publications idiPAZ/ FJD

  1. D. García-Olmo, M. García-Arranz. Cells for curing. From the heart to everything. Anales de pediatría (2011).
  2. García-Olmo DC., García-Olmo D. Circulating nucleic acids in plasma and serum: an intriguing phenomenon. Expert Opin Biol Ther (2012).
  3. Guadalajara H, Herreros D, De-La-Quintana P, Trebol J, Garcia-Arranz M, Garcia-Olmo D. Long-term follow-up of patients undergoing adipose-derived adult stem cell administration to treat complex perianal fistulas.  Int J Colorectal Dis (2012). 
  4. Herreros MD, Garcia-Arranz M, Guadalajara H, De-La-Quintana P, Garcia-Olmo D;  FATT Collaborative Group. Autologous expanded adipose-derived stem cells for the treatment of complex cryptoglandular perianal fistulas: a phase III randomized clinical trial (FATT 1: fistula Advanced Therapy Trial 1) and long-term evaluation. Dis Colon Rectum (2012). 
  5. De la Portilla F, Alba F, García-Olmo D, Herrerías JM, González FX, Galindo A. Expanded allogeneic adipose-derived stem cells (eASCs) for the treatment of complex perianal fistula in Crohn's disease: results from a multicenter phase I/IIa clinical trial. Int J Colorectal Dis (2013). 
  6. García-Olmo DC, García-Olmo D. Biological role of cell-free nucleic acids in cancer: the theory of genometastasis. Crit Rev Oncog (2013).
  7. García-Olmo DC, Picazo MG, Toboso I, Asensio AI, García-Olmo D. Quantitation of cell-free DNA and RNA in plasma during tumor progression in rats. Mol Cancer (2013).
  8. Georgiev-Hristov T, García-Arranz M, García-Olmo D. Adipose tissue-derived products for complex fistula treatment. Tech Coloproctol (2013).
  9. Barba-Recreo P, Del Castillo Pardo de Vera JL, García-Arranz M, Yébenes L, Burgueño M. Zoledronic acid - related osteonecrosis of the jaws.Experimental model with dental extractions in rats. J Craniomaxillofac Surg (2014).
  10. Salazar-Álvarez AE, Riera-del-Moral LF, García-Arranz M, Alvarez-García J, Concepción-Rodriguez NA, Riera-de-Cubas L. Use of platelet-rich plasma in the healing of chronic ulcers of the lower extremity. Actas Dermosifiliogr (2014).
  11. Barco R, Encinas C, Valencia M, Carrascal MT, García-Arranz M, Antuña S. Use of adipose-derived stem cells in an experimental rotator cuff fracture animal model. Rev Esp Cir Ortop Traumatol (2014).

Publications UC3M

  1. Di WL, Semenova E, Larcher F, Del Rio M, Harper JI, Thrasher AJ, Qasim W. Hum  Human involucrin promoter mediates repression-resistant and compartment-specific LEKTI expression. Gene Ther (2012).
  2.  Martínez-Santamaría L, Guerrero-Aspizua S, Del Río M. Skin bioengineering: preclinical and clinical applications.  Actas Dermosifiliogr (2012). 
  3. Marcela Del Rio y Fernando Larcher. What Is New and Hot in Epidermolysis Bullosa?. On line. Página web: Access Dermatology, professional Dermatology knowledge.
  4. Echeverría-García B, Vicente A, Hernández A, Mascaró JM, Colmenero I, Terrón A, Escámez MJ, Del Río M, González-Enseñat MA, Torrelo A. Epidermolysis Bullosa Simplex with Mottled Pigmentation: A Family Report and Review. Pediatr Dermatol (2012).
  5. Buitrago-Pérez Á, Hachimi M, Dueñas M, Lloveras B, Santos A, Holguín A, Duarte B, Santiago JL, Akgül B, Rodríguez-Peralto JL, Storey A, Ribas C, Larcher F, del Rio M, Paramio JM, García-Escudero R. A humanized mouse model of HPV-associated pathology driven by E7 expression.  PLoS One (2012).
  6.  Aufenvenne K, Rice RH, Hausser I, Oji V, Hennies HC, Rio MD, Traupe H, Larcher F. Long-term faithful recapitulation of transglutaminase 1-deficient lamellar ichthyosis in a skin-humanized mouse model, and insights from proteomic studies. J Invest Dermatol (2012).
  7. Warrick E, Garcia M, Chagnoleau C, Chevallier O, Bergoglio V, Sartori D, Mavilio F, Angulo JF, Avril MF, Sarasin A, Larcher F, Del Rio M, Bernerd F, Magnaldo T. Preclinical corrective gene transfer in xeroderma pigmentosum human skin stem cells.  Mol Ther (2012).
  8.  Has C, Castiglia D, del Rio M, Diez MG, Piccinni E, Kiritsi D, Kohlhase J, Itin P, Martin L, Fischer J, Zambruno G, Bruckner-Tuderman L. Kindler syndrome: extension of FERMT1 mutational spectrum and natural history. Hum Mutat. (2011). 
  9. Sara Guerrero-Aspizua, Marta Carretero, Marcela Del Río. Stem cells in Skin Tisular Engineering.  "Hot Topics in Cell Biology" Editors: José Becerra and Leonor Santos-Ruiz. Editorial: Chartridge Books Oxford.  Páginas 166-180.
  10. Peña I, de Villalaín L, García E, Junquera LM, de Vicente JC. Use of autologous skin equivalents with artificial dermal matrix (INTEGRA) in donor site coverage in radial forearm free flaps: preliminary cases. J Oral Maxillofac Surg (2012). 
  11. González-Rodríguez S, Llames S, Hidalgo A, Baamonde A, Menéndez L.  Potentiation of acute morphine-induced analgesia measured by a thermal test in bone cancer-bearing mice. Fundam Clin Pharmacol (2012). 
  12. Peña I, Junquera LM, Llorente S, de Villalaín L, de Vicente JC, Llames S. Clinical outcomes after the use of complete autologous oral mucosa equivalents: Preliminary cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2012). 
  13. García-Zaragoza E, Pérez-Tavarez R, Ballester A, Lafarga V, Jiménez-Reinoso A, Ramírez A, Murillas R, Gallego MI. Intraepithelial paracrine Hedgehog signaling induces the expansion of ciliated cells that express diverse progenitor cell markers in the basal epithelium of the mouse mammary gland.  Dev Biol (2012). 
  14. Sanchez-Jimeno C, Cuadrado-Corrales N, Aller E, García M, Escámez MJ, Illera N, Trujillo-Tiebas MJ, Ayuso C, Millán JM, Del Río M. Recessive dystrophic epidermolysis bullosa: the origin of the c.6527insC mutation in the Spanish population. Br J Dermatol (2013) 
  15.   Carretero M, Guerrero-Aspizua S, Del Río M. Bioengineered skin humanized model of psoriasis. Methods Mol Biol (2013). 
  16. Martínez-Santamaría L, Conti CJ, Llames S, García E, Retamosa L, Holguín A, Illera N, Duarte B, Camblor L, Llaneza JM, Jorcano JL, Larcher F, Meana A, Escámez MJ, Del Río M. The regenerative potential of fibroblasts in a new diabetes-induced delayed humanised wound healing model. Exp Dermatol (2013). 
  17. Hernández-Martín A, Torrelo-Fernández A, de Lucas-Laguna R, Casco F, González-Sarmiento R, Vega A, Pedreira-Massa JL, de Unamuno-Pérez P, Larcher F, Arroyo I, Traupe H. First Symposium of Ichthyosis Experts. Actas Dermosifiliogr (2013).  
  18. Bracke S, Desmet E, Guerrero-Aspizua S, Tjabringa SG, Schalkwijk J, Van Gele M, Carretero M, Lambert J. Identifying targets for topical RNAi therapeutics in psoriasis: assessment of a new in vitro psoriasis model. Arch Dermatol Res (2013). 
  19. Coluccio A, Miselli F, Lombardo A, Marconi A, Malagoli Tagliazucchi G, Gonçalves MA, Pincelli C, Maruggi G, Del Rio M, Naldini L, Larcher F, Mavilio F. Targeted gene addition in human epithelial stem cells by zinc-finger nuclease-mediated homologous recombination. Mol Ther. (2013).
  20. Chamorro C, Almarza D, Duarte B, Llames SG, Murillas R, García M, Cigudosa JC, Espinosa-Hevia L, Escámez MJ, Mencía A, Meana A, García-Escudero R, Moro R, Conti CJ, Del Río M, Larcher F. Keratinocyte cell lines derived from severe generalized recessive epidermolysis bullosa patients carrying a highly recurrent COL7A1 homozygous mutation: models to assess cell and gene therapies in vitro and in vivo. Exp Dermatol. (2013).
  21. Aufenvenne K, Larcher F, Hausser I, Duarte B, Oji V, Nikolenko H, Del Rio M, Dathe M, Traupe H. Topical enzyme-replacement therapy restores transglutaminase 1 activity and corrects architecture of transglutaminase-1-deficient skin grafts.  Am J Hum Genet. (2013). 
  22. Echeverría-García B, Vicente A, Hernández Á, Mascaró JM, Colmenero I, Terrón A, Escámez MJ, del Río M, González-Enseñat MA, Torrelo A. Epidermolysis bullosa simplex with mottled pigmentation: a family report and review. Pediatr Dermatol. (2013).
  23. Hernandez-Martín A, Aranegui B, Escámez MJ, de Lucas R, Vicente A, Rodríguez-Díaz E, Bernabeu-Wittel J, Gonzalez-Hermosa R, García-Patos V, Ginarte  M, Mascaró JM Jr, Corredera C, Baselga E, Santiago JL, Chaves A, Román C, Evole M, Martin-Santiago A, Torrelo A, Del Río M, Feito M, Gonzalez-Enseñat . Prevalence of dystrophic epidermolysis bullosa in Spain: a population-based study using the 3-source capture-recapture method. Evidence of a need for improvement in care. Actas Dermosifiliogr. (2013). 
  24. Gosty?ski A, Llames S, García M, Escamez MJ, Martinez-Santamaria L, Nijenhuis M, Meana A, Pas HH, Larcher F, Pasmooij AM, Jonkman MF, Del Rio M. Long-term survival of type XVII collagen revertant cells in an animal model of revertant cell therapy. J Invest Dermatol. (2014). 
  25. Gosty?ski A, Pasmooij AM, Del Rio M, Diercks GF, Pas HH, Jonkman MF. Pigmentation and melanocyte supply to the epidermis depend on type XVII collagen. Exp Dermatol. (2014).
  26. Llames S, Recuero I, Romance A, García E, Peña I, Del Valle AF, Meana A, Larcher F, Del Río M. Tissue-engineered oral mucosa for mucosal reconstruction in a pediatric patient with hemifacial microsomia and ankyloglossia. Cleft Palate Craniofac J. (2014).
  27. Puig-Butille JA, Escámez MJ, Garcia-Garcia F, Tell-Marti G, Fabra À, Martínez-Santamaría L, Badenas C, Aguilera P, Pevida M, Dopazo J, del Río M, Puig S. Capturing the biological impact of CDKN2A and MC1R genes as an early predisposing event in melanoma and non melanoma skin cancer. Oncotarget. (2014).
  28. Bracke S, Carretero M, Guerrero-Aspizua S, Desmet E, Illera N, Navarro M, Lambert J, Del Rio M. Targeted silencing of DEFB4 in a bioengineered skin-humanized mouse model for psoriasis: development of siRNA SECosome-based novel therapies. Exp Dermatol. (2014 ).
  29. Chiaverini C, Charlesworth A, Fernandez A, Barbarot S, Bessis D, Bodemer C, Bursztejn AC, Cobo AM, Del Rio M, D'Incan M, Labrèze C, Langlet C, Mazereeuw J, Miquel J, Vabres P, Meneguzzi G, Lacour JP. Aplasia cutis congenita with dystrophic epidermolysis bullosa: clinical and mutational study. Br J Dermatol. (2014).
  30. Martín-Mateos P, Crespo-Garcia S, Ruiz-Llata M, Lopez-Fernandez JR, Jorcano JL, Del Rio M, Larcher F, Acedo P. Remote diffuse reflectance spectroscopy sensor for tissue engineering monitoring based on blind signal separation. Biomed Opt Express. (2014).
  31. Kiritsi D, Garcia M, Brander R, Has C, Meijer R, Jose Escámez M, Kohlhase J, van den Akker PC, Scheffer H, Jonkman MF, del Rio M, Bruckner-Tuderman L, Pasmooij AM. Mechanisms of natural gene therapy in dystrophic epidermolysis bullosa. J Invest Dermatol. (2014).
  32. Duarte B, Miselli F, Murillas R, Espinosa-Hevia L, Cigudosa JC, Recchia A, Del Río M, Larcher F. Long-term skin regeneration from a gene-targeted human epidermal stem cell clone. Mol Ther. (2014).
  33. Zapatero-Solana E, García-Giménez J, Guerrero-Aspizua S, García M, Toll A, Baselga E, Durán-Moreno M, Markovic J, García-Verdugo J, Conti CJ, Has C, Larcher F, Pallardó FV, Del Rio M. Oxidative stress and mitochondrial dysfunction in Kindler syndrome. Orphanet J Rare Dis. (2014).

Publications UCM

  1. García-Ceca J, Alfaro D, Montero-Herradón S, Zapata AG. Eph/ephrinB signalling is involved in the survival of thymic epithelial cells. Immunol Cell Biol (2013).  
  2. Cejalvo T, Munoz JJ, Tobajas E, Fanlo L, Alfaro D, García-Ceca J, Zapata A. Ephrin-B-dependent thymic epithelial cell-thymocyte interactions are necessary for correct T cell differentiation and thymus histology organization: relevance for thymic cortex development. J Immunol (2013).        
  3. Peralta M, Steed E, Harlepp S, González-Rosa JM, Monduc F, Ariza-Cosano A, Cortés A, Rayón T, Gómez-Skarmeta JL, Zapata A, Vermot J, Mercader N. Heartbeat-driven pericardiac fluid forces contribute to epicardium morphogenesis. Curr Biol.  (2013). 
  4. Martinelli P, Cañamero M, del Pozo N, Madriles F, Zapata A, Real FX. Gata6 is required for complete acinar differentiation and maintenance of the exocrine pancreas in adult mice. Gut. (2013).
  5. Zapata A. Immunity of reptiles and birds.In Comparative Immunobiology. Ottaviani E, Ed PICCIN, Italy. (2013). 
  6. Ramos-Medina R; García-Segovia A; León J; Alonso B; Tejera-Alhambra M; Gil J; Caputo J; Seyfferth A; Vicente A; Alonso J; Caballero P; Fernández-Cruz E; Ortíz-Quintana L; Sánchez-Ramón S. New decicsion-tree model for defining the risk of Reproductive Failure. American Jornal of Reproductive Inmunology (2013).              
  7. Peces-Peña MD1, De la Cuadra-Blanco C2, Vicente A3, Mérida-Velasco JR2 .  Human development of the ciliary body: morphogical changes in the distal portion of the optic cup.  Cell Tissue Organs  (2013).    
  8. María Ángeles Vicente López; Miriam Nohemi Vázquez Garcia; Gustavo J. Melen; Ana Entrena; Martinez; Isabel Cubillo; Javier Garcia Castro; Manuel Ramírez; Agustin Gregorio Zapata. Mesenchymal stromal cells derived from the bone marrow of acute lymphoblastic leukemia patients show altered BMP4 production: Correlations with the course of disease. PLoS ONE. (2014). 
  9. Martínez VG, Hidalgo L, Valencia J, Hernández-López C, Entrena A, del Amo BG, Zapata AG, Vicente A, Sacedón R, Varas A.  Autocrine activation of canonical BMP signalling regulates PD-L1 and PD-L2 expression in human dendritic cells. Eur J Immunol. (2014).
  10. Munoz JJ, Cejalvo T, Tobajas E, Fanlo L, Cortés A, Zapata A. A branching morphogenesis program underlies thymic organogenesis and cortex-medulla differentiation. Histol. & Histopathol.  (2014).
  11. Zapata A. The Adult Hematopoietic Niches-cellular composition, histological organization and physiological regulation (chapter). Adult Stem Cell Niches, (2014). 
  12. Icardo JM, Wong WP, Colvee E, Loong AM, Zapata AG, Ip YK. Lympho-granulocytic tissue associated with the wall of the spiral valve in the African lungfish Protopterus annectens. Cell Tissue Res. (2014).
  13. Cejalvo T, Munoz JJ, Tobajas E, Alfaro D, García-Ceca J, Zapata A. Conditional deletion of EphrinB1 and/or EphrinB2 in either thymocytes or TECs alters the organization of thymic medulla and favours the appearance of epithelial cysts. C Histochemistry and Cell Biology (2014).
  14. Robson NC, Hidalgo L, Mc Alpine T, Wei H, Martinez VG, Entrena A, Melen GJ, MacDonald AS, Phythian-Adams A, Sacedón R, Maraskovsky E, Cebon J, Ramirez M, Vicente A, Varas A. Optimal effector functions in human natural killer cells rely upon autocrine bone morphogenetic protein signaling. Cancer Research  (2014).
  15. Valencia J, Martínez VG, Hidalgo L, Hernández-López C, Canseco NM, Vicente A, Varas A, Sacedón R.   Wnt5a signaling increases IL-12 secretion by human dendritic cells and enhances IFN-¿ production by CD4+ T cells. Immunol Lett. (2014).
  16. Mirones I, Angel Rodríguez-Milla M, Cubillo I, Mariñas-Pardo L, de la Cueva T, Zapata A, González C, Ramírez M, García-Castro J. Dopamine mobilizes mesenchymal progenitor cells through D2-class receptors and their PI3K/AKT pathway. Stem Cells. (2014).
  17. Munoz JJ, Cejalvo T, Tobajas E, Fanlo L, Cortés A, Zapata A. A branching morphogenesis program underlies thymic organogenesis and cortex-medulla differentiation. Histol. & Histopathol. (2014).
  18. Bednarek D, González-Rosa JM, Guzmán G, Gutiérrez-Gutiérrez O, Aguado T, Cortés A, Zapata A, Jiménez-Borreguero J, Mercader N, Flores I.Telomerase is essential for zebrafish heart regeneration. Nature Communications (submitted). (2014).
  19. Alfaro D, García-Ceca J, Farias-de-Oliveira DA, Terra-Granado E, Montero S, Cotta-de-Almeida V, Savino W, Zapata A. EphB2 and EphB3 play an important role in the lymphoid seeding of murine adult thymus. J Leuk Biol. (submitted). (2014).